4CTJ
DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| C | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAM A 1263 |
| Chain | Residue |
| A | SER56 |
| A | HIS110 |
| A | LYS130 |
| A | ASP131 |
| A | VAL132 |
| A | PHE133 |
| A | ASP146 |
| A | HOH2216 |
| A | HOH2221 |
| A | HOH2253 |
| A | HOH2435 |
| A | GLY58 |
| A | HOH2451 |
| A | GLY81 |
| A | CYS82 |
| A | GLY83 |
| A | GLY86 |
| A | TRP87 |
| A | THR104 |
| A | LYS105 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAM C 1263 |
| Chain | Residue |
| C | SER56 |
| C | GLY58 |
| C | GLY81 |
| C | CYS82 |
| C | GLY83 |
| C | GLY86 |
| C | TRP87 |
| C | THR104 |
| C | LYS105 |
| C | LYS130 |
| C | ASP131 |
| C | VAL132 |
| C | PHE133 |
| C | ASP146 |
| C | ILE147 |
| C | HOH2201 |
| C | HOH2207 |
| C | HOH2233 |
| C | HOH2235 |
| C | HOH2236 |
| C | HOH2415 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 3A9 A 1264 |
| Chain | Residue |
| A | GLY107 |
| A | GLU112 |
| A | SER128 |
| A | GLY129 |
| A | LEU237 |
| A | ARG241 |
| A | MET244 |
| A | ARG247 |
| A | HOH2415 |
| A | HOH2426 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA A 1265 |
| Chain | Residue |
| A | GLU111 |
