4CSM
YEAST CHORISMATE MUTASE + TYR + ENDOOXABICYCLIC INHIBITOR
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004106 | molecular_function | chorismate mutase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0006571 | biological_process | tyrosine biosynthetic process |
A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
A | 0009094 | biological_process | L-phenylalanine biosynthetic process |
A | 0016853 | molecular_function | isomerase activity |
A | 0046417 | biological_process | chorismate metabolic process |
A | 0072545 | molecular_function | L-tyrosine binding |
A | 0120284 | molecular_function | tryptophan binding |
B | 0004106 | molecular_function | chorismate mutase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0006571 | biological_process | tyrosine biosynthetic process |
B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
B | 0009094 | biological_process | L-phenylalanine biosynthetic process |
B | 0016853 | molecular_function | isomerase activity |
B | 0046417 | biological_process | chorismate metabolic process |
B | 0072545 | molecular_function | L-tyrosine binding |
B | 0120284 | molecular_function | tryptophan binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE TYR A 300 |
Chain | Residue |
A | ARG76 |
A | TYR100 |
A | ASN138 |
A | ASN139 |
A | PHE140 |
A | GLY141 |
A | SER142 |
A | THR145 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE TYR B 300 |
Chain | Residue |
B | ARG76 |
B | GLU82 |
B | ILE98 |
B | ASN138 |
B | ASN139 |
B | PHE140 |
B | GLY141 |
B | SER142 |
B | THR145 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TSA A 400 |
Chain | Residue |
A | ARG16 |
A | ARG157 |
A | LYS168 |
A | THR193 |
A | ASN194 |
A | GLU198 |
A | ILE201 |
A | ILE239 |
A | LYS243 |
A | GLU246 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TSA B 400 |
Chain | Residue |
B | ARG16 |
B | ARG157 |
B | LYS168 |
B | THR193 |
B | ASN194 |
B | GLU198 |
B | ILE201 |
B | ILE239 |
B | THR242 |
B | LYS243 |
B | GLU246 |
site_id | ACT |
Number of Residues | 13 |
Details | ACTIVE SITE. |
Chain | Residue |
A | LEU12 |
A | VAL164 |
A | ARG157 |
A | THR242 |
A | GLU246 |
A | LYS243 |
A | ILE239 |
A | ASN194 |
A | GLU198 |
A | LYS168 |
A | VAL197 |
A | ARG16 |
A | LEU19 |
site_id | REG |
Number of Residues | 7 |
Details | REGULATORY BINDING SITE FOR TRYPTOPHAN AND TYROSINE. |
Chain | Residue |
A | ILE74 |
A | ARG75 |
A | ARG76 |
A | THR145 |
A | GLY141 |
A | SER142 |
A | ASN139 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8622937, ECO:0007744|PDB:2CSM |
Chain | Residue | Details |
A | ASN139 | |
A | GLY141 | |
A | SER142 | |
A | THR145 | |
B | ARG75 | |
B | ARG76 | |
B | ASN139 | |
B | GLY141 | |
B | SER142 | |
B | THR145 | |
A | ARG75 | |
A | ARG76 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:7971967, ECO:0007744|PDB:1CSM |
Chain | Residue | Details |
A | ASN138 | |
B | ASN138 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 81 |
Chain | Residue | Details |
A | ARG16 | hydrogen bond donor, transition state stabiliser |
A | ARG157 | hydrogen bond donor, transition state stabiliser |
A | LYS168 | hydrogen bond donor, transition state stabiliser |
A | ASN194 | transition state stabiliser |
A | GLU198 | hydrogen bond acceptor, transition state stabiliser |
A | THR242 | transition state stabiliser |
A | GLU246 | hydrogen bond donor, transition state stabiliser |
site_id | MCSA2 |
Number of Residues | 7 |
Details | M-CSA 81 |
Chain | Residue | Details |
B | ARG16 | hydrogen bond donor, transition state stabiliser |
B | ARG157 | hydrogen bond donor, transition state stabiliser |
B | LYS168 | hydrogen bond donor, transition state stabiliser |
B | ASN194 | transition state stabiliser |
B | GLU198 | hydrogen bond acceptor, transition state stabiliser |
B | THR242 | transition state stabiliser |
B | GLU246 | hydrogen bond donor, transition state stabiliser |