4CRS

Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE AGS A 1985

Chain	Residue
A	SER644
A	LYS686
A	MET737
A	GLU738
A	ALA740
A	ASP744
A	ASP786
A	ASN787
A	LEU789
A	ASP800
A	PHE946
A	LEU663
A	MG1986
A	LEU664
A	GLY666
A	HIS667
A	PHE668
A	GLY669
A	VAL671
A	ALA684

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1986

Chain	Residue
A	ASN787
A	ASP800
A	AGS1985

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1987

Chain	Residue
A	ARG893
A	ASN895
A	ARG898
A	ARG898

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvYrDLKldNLLL

Chain	Residue	Details
A	ILE778-LEU790

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP782

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU663
A	LYS686

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by caspase-3

Chain	Residue	Details
A	ASP700

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:10792047

Chain	Residue	Details
A	TPO816

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER952

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TPO958

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