4CRN

Cryo-EM of a pretermination complex with eRF1 and eRF3

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
P	0003747	molecular_function	translation release factor activity
P	0003924	molecular_function	GTPase activity
P	0005525	molecular_function	GTP binding
P	0006415	biological_process	translational termination
X	0002184	biological_process	cytoplasmic translational termination
X	0003747	molecular_function	translation release factor activity
X	0004045	molecular_function	peptidyl-tRNA hydrolase activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006353	biological_process	DNA-templated transcription termination
X	0006412	biological_process	translation
X	0006415	biological_process	translational termination
X	0009302	biological_process	sno(s)RNA transcription
X	0010494	cellular_component	cytoplasmic stress granule
X	0016070	biological_process	RNA metabolic process
X	0016149	molecular_function	translation release factor activity, codon specific
X	0018444	cellular_component	translation release factor complex
X	1990825	molecular_function	sequence-specific mRNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GNP P 1685

Chain	Residue
P	HIS267
P	TYR307
P	LYS323
P	THR324
P	ILE325
P	ASP343
P	ALA344
P	PRO345
P	GLY346
P	LYS348
P	ASN405
P	VAL268
P	LYS406
P	ASP409
P	GLY448
P	ASP269
P	ALA270
P	GLY271
P	LYS272
P	SER273
P	GLN304
P	GLY305

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Functional Information from PROSITE/UniProt

site_id	PS00301
Number of Residues	16
Details	G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DTnkeERnDGKTIevG

Chain	Residue	Details
P	ASP313-GLY328

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	226
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O74718","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"15509572","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16321977","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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