4CRM

Cryo-EM of a pre-recycling complex with eRF1 and ABCE1

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000054	biological_process	ribosomal subunit export from nucleus
P	0000166	molecular_function	nucleotide binding
P	0003743	molecular_function	translation initiation factor activity
P	0005506	molecular_function	iron ion binding
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
P	0006364	biological_process	rRNA processing
P	0006412	biological_process	translation
P	0006413	biological_process	translational initiation
P	0006415	biological_process	translational termination
P	0016887	molecular_function	ATP hydrolysis activity
P	0032790	biological_process	ribosome disassembly
P	0042254	biological_process	ribosome biogenesis
P	0042273	biological_process	ribosomal large subunit biogenesis
P	0043024	molecular_function	ribosomal small subunit binding
P	0045727	biological_process	positive regulation of translation
P	0060255	biological_process	regulation of macromolecule metabolic process
X	0003747	molecular_function	translation release factor activity
X	0006415	biological_process	translational termination

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ATP P 1609

Chain	Residue
P	HOH1903
P	THR118
P	SER299
P	MG1613
P	TYR87
P	PHE92
P	ASN112
P	GLY113
P	ILE114
P	GLY115
P	LYS116
P	SER117

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 P 1610

Chain	Residue
P	CYS29
P	CYS38
P	ILE50
P	CYS55
P	CYS58
P	GLY59
P	CYS61
P	ILE72

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SF4 P 1611

Chain	Residue
P	CYS16
P	LYS17
P	PRO18
P	CYS21
P	ARG22
P	GLU24
P	CYS25
P	CYS65
P	PRO66
P	PHE67
P	ALA69

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP P 1612

Chain	Residue
P	ARG217
P	GLN363
P	PHE366
P	GLU386
P	ASN387
P	GLY388
P	THR389
P	GLY390
P	LYS391
P	THR392
P	THR393
P	SER546

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG P 1613

Chain	Residue
P	SER117
P	GLN171
P	ATP1609

---

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiGCGiCVkKCP

Chain	Residue	Details
P	CYS55-PRO66

---

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGELQRVAIVLAL

Chain	Residue	Details
P	LEU468-LEU482

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	250
Details	Domain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	223
Details	Domain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"15509572","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16321977","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---