4COM

Crystal structure of the anaerobic ribonucleotide reductase from Thermotoga maritima with MES in the active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004748	molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
A	0006260	biological_process	DNA replication
A	0008998	molecular_function	ribonucleoside-triphosphate reductase (thioredoxin) activity
A	0009265	biological_process	2'-deoxyribonucleotide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0031250	cellular_component	anaerobic ribonucleoside-triphosphate reductase complex
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004748	molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
B	0006260	biological_process	DNA replication
B	0008998	molecular_function	ribonucleoside-triphosphate reductase (thioredoxin) activity
B	0009265	biological_process	2'-deoxyribonucleotide biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0031250	cellular_component	anaerobic ribonucleoside-triphosphate reductase complex
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 700

Chain	Residue
A	CYS594
A	HIS598
A	CYS605
A	CYS608

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 652

Chain	Residue
B	CYS594
B	HIS598
B	CYS605
B	CYS608

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES A 1634

Chain	Residue
A	TYR124
A	TYR227
A	PRO498
A	ALA499
A	GLU500
A	HOH2068
A	HOH2329
A	HIS114

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MES B 1631

Chain	Residue
B	HIS114
B	TYR124
B	TYR227
B	VAL497
B	PRO498
B	ALA499
B	GLU500
B	HOH2066
B	HOH2075
B	HOH2107
B	HOH2275
B	HOH2278

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE B 1632

Chain	Residue
B	ARG221
B	HOH2128
B	HOH2328

---