4COG
Crystal structure of kynurenine formamidase from Burkholderia cenocepacia
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004061 | molecular_function | arylformamidase activity |
A | 0004328 | molecular_function | formamidase activity |
A | 0006569 | biological_process | tryptophan catabolic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
A | 0043420 | biological_process | anthranilate metabolic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0004061 | molecular_function | arylformamidase activity |
B | 0004328 | molecular_function | formamidase activity |
B | 0006569 | biological_process | tryptophan catabolic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0016787 | molecular_function | hydrolase activity |
B | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
B | 0043420 | biological_process | anthranilate metabolic process |
B | 0046872 | molecular_function | metal ion binding |
C | 0004061 | molecular_function | arylformamidase activity |
C | 0004328 | molecular_function | formamidase activity |
C | 0006569 | biological_process | tryptophan catabolic process |
C | 0008270 | molecular_function | zinc ion binding |
C | 0016787 | molecular_function | hydrolase activity |
C | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
C | 0043420 | biological_process | anthranilate metabolic process |
C | 0046872 | molecular_function | metal ion binding |
D | 0004061 | molecular_function | arylformamidase activity |
D | 0004328 | molecular_function | formamidase activity |
D | 0006569 | biological_process | tryptophan catabolic process |
D | 0008270 | molecular_function | zinc ion binding |
D | 0016787 | molecular_function | hydrolase activity |
D | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
D | 0043420 | biological_process | anthranilate metabolic process |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 401 |
Chain | Residue |
A | ASP54 |
A | HIS160 |
A | GLU172 |
A | CD402 |
A | GOL1213 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CD A 402 |
Chain | Residue |
A | ZN401 |
A | GOL1213 |
A | HIS48 |
A | HIS52 |
A | ASP54 |
A | GLU172 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 401 |
Chain | Residue |
B | ASP54 |
B | HIS160 |
B | GLU172 |
B | CD402 |
B | GOL1213 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CD B 402 |
Chain | Residue |
B | HIS48 |
B | HIS52 |
B | ASP54 |
B | GLU172 |
B | ZN401 |
B | GOL1213 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN C 401 |
Chain | Residue |
C | ASP54 |
C | HIS160 |
C | GLU172 |
C | CD402 |
C | GOL1213 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CD C 402 |
Chain | Residue |
C | HIS48 |
C | HIS52 |
C | ASP54 |
C | GLU172 |
C | ZN401 |
C | GOL1213 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN D 401 |
Chain | Residue |
D | ASP54 |
D | HIS160 |
D | GLU172 |
D | CD402 |
D | GOL1214 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CD D 402 |
Chain | Residue |
D | HIS48 |
D | HIS52 |
D | ASP54 |
D | GLU172 |
D | ZN401 |
D | GOL1214 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 1210 |
Chain | Residue |
C | HIS137 |
C | HOH2163 |
C | HOH2215 |
C | HOH2216 |
C | HOH2217 |
C | HOH2277 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 1210 |
Chain | Residue |
B | ASP60 |
B | ASP62 |
B | HOH2107 |
B | HOH2108 |
B | HOH2109 |
B | HOH2112 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 1211 |
Chain | Residue |
B | HIS137 |
B | HOH2204 |
B | HOH2205 |
B | HOH2206 |
B | HOH2207 |
B | HOH2264 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 1210 |
Chain | Residue |
A | HIS137 |
A | HOH2185 |
A | HOH2224 |
A | HOH2225 |
A | HOH2275 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 1211 |
Chain | Residue |
A | ASP60 |
A | ASP62 |
A | HOH2131 |
A | HOH2132 |
A | HOH2133 |
A | HOH2137 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 1210 |
Chain | Residue |
D | ASP60 |
D | ASP62 |
D | HOH2082 |
D | HOH2083 |
D | HOH2084 |
D | HOH2088 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 1211 |
Chain | Residue |
D | HIS137 |
D | HOH2133 |
D | HOH2179 |
D | HOH2180 |
D | HOH2181 |
D | HOH2234 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 1211 |
Chain | Residue |
C | ASP60 |
C | ASP62 |
C | HOH2114 |
C | HOH2116 |
C | HOH2117 |
C | HOH2123 |
site_id | BC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 1212 |
Chain | Residue |
A | TRP18 |
A | ASP21 |
A | HIS48 |
A | HIS58 |
A | GOL1213 |
A | HOH2117 |
A | HOH2276 |
B | VAL40 |
site_id | BC9 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GOL A 1213 |
Chain | Residue |
A | HIS48 |
A | HIS52 |
A | ASP54 |
A | HIS58 |
A | PRO147 |
A | SER148 |
A | HIS160 |
A | GLU172 |
A | ZN401 |
A | CD402 |
A | GOL1212 |
site_id | CC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL A 1214 |
Chain | Residue |
A | PRO9 |
A | GLY50 |
A | TYR111 |
A | ALA115 |
A | ASP145 |
A | THR146 |
A | GLY173 |
A | ILE174 |
A | HOH2194 |
A | HOH2277 |
site_id | CC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B 1212 |
Chain | Residue |
A | VAL40 |
B | TRP18 |
B | ASP21 |
B | HIS48 |
B | HIS58 |
B | GOL1213 |
B | HOH2090 |
B | HOH2265 |
site_id | CC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GOL B 1213 |
Chain | Residue |
B | HIS48 |
B | HIS52 |
B | ASP54 |
B | HIS58 |
B | PRO147 |
B | SER148 |
B | HIS160 |
B | GLU172 |
B | ZN401 |
B | CD402 |
B | GOL1212 |
site_id | CC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GOL B 1214 |
Chain | Residue |
B | PRO9 |
B | GLY50 |
B | TYR111 |
B | ALA115 |
B | ASP145 |
B | THR146 |
B | GLY173 |
B | ILE174 |
B | HOH2170 |
B | HOH2266 |
B | HOH2267 |
site_id | CC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL C 1212 |
Chain | Residue |
C | TRP18 |
C | ASP21 |
C | HIS48 |
C | HIS58 |
C | GOL1213 |
C | HOH2099 |
C | HOH2278 |
D | VAL40 |
site_id | CC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GOL C 1213 |
Chain | Residue |
C | HIS48 |
C | HIS52 |
C | ASP54 |
C | HIS58 |
C | PRO147 |
C | SER148 |
C | HIS160 |
C | GLU172 |
C | ZN401 |
C | CD402 |
C | GOL1212 |
site_id | CC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL C 1214 |
Chain | Residue |
C | PRO9 |
C | GLY50 |
C | ALA115 |
C | ASP145 |
C | THR146 |
C | PRO147 |
C | GLY173 |
C | ILE174 |
C | HOH2186 |
site_id | CC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL D 1212 |
Chain | Residue |
C | VAL40 |
D | TRP18 |
D | ASP21 |
D | HIS48 |
D | HIS58 |
D | GOL1214 |
D | HOH2235 |
site_id | CC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL D 1213 |
Chain | Residue |
D | PRO9 |
D | TYR111 |
D | ALA115 |
D | ASP145 |
D | THR146 |
D | GLY173 |
D | ILE174 |
D | HOH2146 |
D | HOH2236 |
site_id | DC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GOL D 1214 |
Chain | Residue |
D | HIS48 |
D | HIS52 |
D | ASP54 |
D | HIS58 |
D | PRO147 |
D | SER148 |
D | HIS160 |
D | GLU172 |
D | ZN401 |
D | CD402 |
D | GOL1212 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 1215 |
Chain | Residue |
A | ARG113 |
A | ALA115 |
A | ASP120 |
A | HOH2203 |
site_id | DC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 1216 |
Chain | Residue |
A | ARG79 |
A | ASP183 |
A | HOH2184 |
site_id | DC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO B 1215 |
Chain | Residue |
B | PRO181 |
site_id | DC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 1216 |
Chain | Residue |
B | ARG113 |
B | ALA114 |
B | HOH2172 |
B | HOH2268 |
site_id | DC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 1217 |
Chain | Residue |
A | GLY85 |
A | THR110 |
A | TYR111 |
A | ALA112 |
A | HOH2192 |
A | HOH2195 |
A | HOH2278 |
A | HOH2279 |
site_id | DC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO D 1215 |
Chain | Residue |
D | ALA165 |
D | ARG167 |
D | HOH2209 |
site_id | DC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO D 1216 |
Chain | Residue |
D | PRO9 |
D | PRO10 |
D | THR15 |
D | HOH2019 |
D | HOH2027 |
D | HOH2154 |
D | HOH2156 |
site_id | DC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 1217 |
Chain | Residue |
B | ILE84 |
B | HOH2141 |
site_id | EC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO D 1217 |
Chain | Residue |
D | ARG113 |
D | HOH2066 |
D | HOH2147 |
D | HOH2237 |
D | HOH2238 |
site_id | EC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PEG C 1215 |
Chain | Residue |
C | TRP5 |
C | ASP178 |
C | PRO180 |
C | HOH2279 |
C | HOH2280 |
Functional Information from PROSITE/UniProt
site_id | PS00639 |
Number of Residues | 11 |
Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. AAHGVKLIGID |
Chain | Residue | Details |
A | ALA135-ASP145 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_01969, ECO:0000305|PubMed:24942958 |
Chain | Residue | Details |
A | HIS58 | |
B | HIS58 | |
C | HIS58 | |
D | HIS58 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01969 |
Chain | Residue | Details |
A | TRP18 | |
B | TRP18 | |
C | TRP18 | |
D | TRP18 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01969, ECO:0000269|PubMed:24942958, ECO:0007744|PDB:4COG |
Chain | Residue | Details |
A | HIS48 | |
B | GLU172 | |
C | HIS48 | |
C | HIS52 | |
C | ASP54 | |
C | HIS160 | |
C | GLU172 | |
D | HIS48 | |
D | HIS52 | |
D | ASP54 | |
D | HIS160 | |
A | HIS52 | |
D | GLU172 | |
A | ASP54 | |
A | HIS160 | |
A | GLU172 | |
B | HIS48 | |
B | HIS52 | |
B | ASP54 | |
B | HIS160 |