4COG
Crystal structure of kynurenine formamidase from Burkholderia cenocepacia
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004061 | molecular_function | arylformamidase activity |
| A | 0004328 | molecular_function | formamidase activity |
| A | 0006569 | biological_process | L-tryptophan catabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019441 | biological_process | L-tryptophan catabolic process to kynurenine |
| A | 0043420 | biological_process | anthranilate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004061 | molecular_function | arylformamidase activity |
| B | 0004328 | molecular_function | formamidase activity |
| B | 0006569 | biological_process | L-tryptophan catabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019441 | biological_process | L-tryptophan catabolic process to kynurenine |
| B | 0043420 | biological_process | anthranilate metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004061 | molecular_function | arylformamidase activity |
| C | 0004328 | molecular_function | formamidase activity |
| C | 0006569 | biological_process | L-tryptophan catabolic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019441 | biological_process | L-tryptophan catabolic process to kynurenine |
| C | 0043420 | biological_process | anthranilate metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004061 | molecular_function | arylformamidase activity |
| D | 0004328 | molecular_function | formamidase activity |
| D | 0006569 | biological_process | L-tryptophan catabolic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019441 | biological_process | L-tryptophan catabolic process to kynurenine |
| D | 0043420 | biological_process | anthranilate metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | ASP54 |
| A | HIS160 |
| A | GLU172 |
| A | CD402 |
| A | GOL1213 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD A 402 |
| Chain | Residue |
| A | ZN401 |
| A | GOL1213 |
| A | HIS48 |
| A | HIS52 |
| A | ASP54 |
| A | GLU172 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 401 |
| Chain | Residue |
| B | ASP54 |
| B | HIS160 |
| B | GLU172 |
| B | CD402 |
| B | GOL1213 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD B 402 |
| Chain | Residue |
| B | HIS48 |
| B | HIS52 |
| B | ASP54 |
| B | GLU172 |
| B | ZN401 |
| B | GOL1213 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 401 |
| Chain | Residue |
| C | ASP54 |
| C | HIS160 |
| C | GLU172 |
| C | CD402 |
| C | GOL1213 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD C 402 |
| Chain | Residue |
| C | HIS48 |
| C | HIS52 |
| C | ASP54 |
| C | GLU172 |
| C | ZN401 |
| C | GOL1213 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 401 |
| Chain | Residue |
| D | ASP54 |
| D | HIS160 |
| D | GLU172 |
| D | CD402 |
| D | GOL1214 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD D 402 |
| Chain | Residue |
| D | HIS48 |
| D | HIS52 |
| D | ASP54 |
| D | GLU172 |
| D | ZN401 |
| D | GOL1214 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 1210 |
| Chain | Residue |
| C | HIS137 |
| C | HOH2163 |
| C | HOH2215 |
| C | HOH2216 |
| C | HOH2217 |
| C | HOH2277 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1210 |
| Chain | Residue |
| B | ASP60 |
| B | ASP62 |
| B | HOH2107 |
| B | HOH2108 |
| B | HOH2109 |
| B | HOH2112 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1211 |
| Chain | Residue |
| B | HIS137 |
| B | HOH2204 |
| B | HOH2205 |
| B | HOH2206 |
| B | HOH2207 |
| B | HOH2264 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1210 |
| Chain | Residue |
| A | HIS137 |
| A | HOH2185 |
| A | HOH2224 |
| A | HOH2225 |
| A | HOH2275 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1211 |
| Chain | Residue |
| A | ASP60 |
| A | ASP62 |
| A | HOH2131 |
| A | HOH2132 |
| A | HOH2133 |
| A | HOH2137 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 1210 |
| Chain | Residue |
| D | ASP60 |
| D | ASP62 |
| D | HOH2082 |
| D | HOH2083 |
| D | HOH2084 |
| D | HOH2088 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 1211 |
| Chain | Residue |
| D | HIS137 |
| D | HOH2133 |
| D | HOH2179 |
| D | HOH2180 |
| D | HOH2181 |
| D | HOH2234 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 1211 |
| Chain | Residue |
| C | ASP60 |
| C | ASP62 |
| C | HOH2114 |
| C | HOH2116 |
| C | HOH2117 |
| C | HOH2123 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1212 |
| Chain | Residue |
| A | TRP18 |
| A | ASP21 |
| A | HIS48 |
| A | HIS58 |
| A | GOL1213 |
| A | HOH2117 |
| A | HOH2276 |
| B | VAL40 |
| site_id | BC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 1213 |
| Chain | Residue |
| A | HIS48 |
| A | HIS52 |
| A | ASP54 |
| A | HIS58 |
| A | PRO147 |
| A | SER148 |
| A | HIS160 |
| A | GLU172 |
| A | ZN401 |
| A | CD402 |
| A | GOL1212 |
| site_id | CC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1214 |
| Chain | Residue |
| A | PRO9 |
| A | GLY50 |
| A | TYR111 |
| A | ALA115 |
| A | ASP145 |
| A | THR146 |
| A | GLY173 |
| A | ILE174 |
| A | HOH2194 |
| A | HOH2277 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1212 |
| Chain | Residue |
| A | VAL40 |
| B | TRP18 |
| B | ASP21 |
| B | HIS48 |
| B | HIS58 |
| B | GOL1213 |
| B | HOH2090 |
| B | HOH2265 |
| site_id | CC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 1213 |
| Chain | Residue |
| B | HIS48 |
| B | HIS52 |
| B | ASP54 |
| B | HIS58 |
| B | PRO147 |
| B | SER148 |
| B | HIS160 |
| B | GLU172 |
| B | ZN401 |
| B | CD402 |
| B | GOL1212 |
| site_id | CC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 1214 |
| Chain | Residue |
| B | PRO9 |
| B | GLY50 |
| B | TYR111 |
| B | ALA115 |
| B | ASP145 |
| B | THR146 |
| B | GLY173 |
| B | ILE174 |
| B | HOH2170 |
| B | HOH2266 |
| B | HOH2267 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 1212 |
| Chain | Residue |
| C | TRP18 |
| C | ASP21 |
| C | HIS48 |
| C | HIS58 |
| C | GOL1213 |
| C | HOH2099 |
| C | HOH2278 |
| D | VAL40 |
| site_id | CC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL C 1213 |
| Chain | Residue |
| C | HIS48 |
| C | HIS52 |
| C | ASP54 |
| C | HIS58 |
| C | PRO147 |
| C | SER148 |
| C | HIS160 |
| C | GLU172 |
| C | ZN401 |
| C | CD402 |
| C | GOL1212 |
| site_id | CC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 1214 |
| Chain | Residue |
| C | PRO9 |
| C | GLY50 |
| C | ALA115 |
| C | ASP145 |
| C | THR146 |
| C | PRO147 |
| C | GLY173 |
| C | ILE174 |
| C | HOH2186 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 1212 |
| Chain | Residue |
| C | VAL40 |
| D | TRP18 |
| D | ASP21 |
| D | HIS48 |
| D | HIS58 |
| D | GOL1214 |
| D | HOH2235 |
| site_id | CC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 1213 |
| Chain | Residue |
| D | PRO9 |
| D | TYR111 |
| D | ALA115 |
| D | ASP145 |
| D | THR146 |
| D | GLY173 |
| D | ILE174 |
| D | HOH2146 |
| D | HOH2236 |
| site_id | DC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL D 1214 |
| Chain | Residue |
| D | HIS48 |
| D | HIS52 |
| D | ASP54 |
| D | HIS58 |
| D | PRO147 |
| D | SER148 |
| D | HIS160 |
| D | GLU172 |
| D | ZN401 |
| D | CD402 |
| D | GOL1212 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1215 |
| Chain | Residue |
| A | ARG113 |
| A | ALA115 |
| A | ASP120 |
| A | HOH2203 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1216 |
| Chain | Residue |
| A | ARG79 |
| A | ASP183 |
| A | HOH2184 |
| site_id | DC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 1215 |
| Chain | Residue |
| B | PRO181 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1216 |
| Chain | Residue |
| B | ARG113 |
| B | ALA114 |
| B | HOH2172 |
| B | HOH2268 |
| site_id | DC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1217 |
| Chain | Residue |
| A | GLY85 |
| A | THR110 |
| A | TYR111 |
| A | ALA112 |
| A | HOH2192 |
| A | HOH2195 |
| A | HOH2278 |
| A | HOH2279 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 1215 |
| Chain | Residue |
| D | ALA165 |
| D | ARG167 |
| D | HOH2209 |
| site_id | DC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 1216 |
| Chain | Residue |
| D | PRO9 |
| D | PRO10 |
| D | THR15 |
| D | HOH2019 |
| D | HOH2027 |
| D | HOH2154 |
| D | HOH2156 |
| site_id | DC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 1217 |
| Chain | Residue |
| B | ILE84 |
| B | HOH2141 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 1217 |
| Chain | Residue |
| D | ARG113 |
| D | HOH2066 |
| D | HOH2147 |
| D | HOH2237 |
| D | HOH2238 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG C 1215 |
| Chain | Residue |
| C | TRP5 |
| C | ASP178 |
| C | PRO180 |
| C | HOH2279 |
| C | HOH2280 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. AAHGVKLIGID |
| Chain | Residue | Details |
| A | ALA135-ASP145 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01969","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24942958","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01969","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01969","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24942958","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4COG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
