4CO9

Crystal structure of kynurenine formamidase from Bacillus anthracis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004061	molecular_function	arylformamidase activity
A	0004328	molecular_function	formamidase activity
A	0006569	biological_process	L-tryptophan catabolic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0019441	biological_process	L-tryptophan catabolic process to kynurenine
A	0043420	biological_process	anthranilate metabolic process
A	0046872	molecular_function	metal ion binding
B	0004061	molecular_function	arylformamidase activity
B	0004328	molecular_function	formamidase activity
B	0006569	biological_process	L-tryptophan catabolic process
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0019441	biological_process	L-tryptophan catabolic process to kynurenine
B	0043420	biological_process	anthranilate metabolic process
B	0046872	molecular_function	metal ion binding
C	0004061	molecular_function	arylformamidase activity
C	0004328	molecular_function	formamidase activity
C	0006569	biological_process	L-tryptophan catabolic process
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0019441	biological_process	L-tryptophan catabolic process to kynurenine
C	0043420	biological_process	anthranilate metabolic process
C	0046872	molecular_function	metal ion binding
D	0004061	molecular_function	arylformamidase activity
D	0004328	molecular_function	formamidase activity
D	0006569	biological_process	L-tryptophan catabolic process
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0019441	biological_process	L-tryptophan catabolic process to kynurenine
D	0043420	biological_process	anthranilate metabolic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	ASP56
A	HIS161
A	GLU173
A	ZN402
A	HOH2108
A	HOH2238

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 402

Chain	Residue
A	GLU173
A	ZN401
A	HOH2044
A	HOH2108
A	HIS50
A	HIS54
A	ASP56

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 401

Chain	Residue
B	ASP56
B	HIS161
B	GLU173
B	ZN402
B	HOH2073
B	HOH2147

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN B 402

Chain	Residue
B	HIS50
B	HIS54
B	ASP56
B	GLU173
B	ZN401
B	HOH2037
B	HOH2073

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN C 401

Chain	Residue
C	ASP56
C	HIS161
C	GLU173
C	ZN402
C	HOH2102
C	HOH2201

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN C 402

Chain	Residue
C	HIS50
C	HIS54
C	ASP56
C	GLU173
C	ZN401
C	HOH2048
C	HOH2102

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN D 401

Chain	Residue
D	ASP56
D	HIS161
D	GLU173
D	ZN402
D	HOH2075
D	HOH2163

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN D 402

Chain	Residue
D	HIS50
D	HIS54
D	ASP56
D	GLU173
D	ZN401
D	HOH2036
D	HOH2075

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1214

Chain	Residue
A	HOH2119
A	HOH2123
A	HOH2124
A	HOH2291
A	HOH2292
A	HOH2293

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1215

Chain	Residue
A	HOH2269
A	HOH2294
A	HOH2295
A	HOH2296
D	HOH2085
D	HOH2087

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 1211

Chain	Residue
C	HOH2108
C	HOH2109
C	HOH2118
C	HOH2238
C	HOH2239
C	HOH2240

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 1210

Chain	Residue
C	GLY38
C	HOH2086
C	HOH2087
C	HOH2088
C	HOH2089
C	HOH2237

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1210

Chain	Residue
A	GLY38
A	HOH2088
A	HOH2089
A	HOH2090
A	HOH2091
A	HOH2288

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DIO A 1211

Chain	Residue
A	TRP6
A	GLU186
A	ARG207
A	HOH2273
B	TRP6
B	GLU186
B	ARG207

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DIO D 1210

Chain	Residue
C	ARG207
D	TRP6
D	GLU186

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GXT A 1212

Chain	Residue
A	GLY183
A	ASP184
A	HOH2270
A	HOH2289
D	ASP64

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GXT A 1213

Chain	Residue
A	GLU102
A	HOH2194

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GXT D 1211

Chain	Residue
D	PRO12
D	HOH2020

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01969","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24942958","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24942958","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01969","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24942958","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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