4CMV
Crystal structure of Rv3378c
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016102 | biological_process | diterpenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0035440 | biological_process | tuberculosinol biosynthetic process |
| A | 0062204 | molecular_function | (13S)-vitexifolin A synthase activity |
| B | 0016102 | biological_process | diterpenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0035440 | biological_process | tuberculosinol biosynthetic process |
| B | 0062204 | molecular_function | (13S)-vitexifolin A synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG A 1296 |
| Chain | Residue |
| A | CYS157 |
| A | HOH2100 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG B 1295 |
| Chain | Residue |
| B | CYS157 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 1296 |
| Chain | Residue |
| B | HIS117 |
| B | GLU196 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 1297 |
| Chain | Residue |
| B | PHE67 |
| B | HIS154 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 1298 |
| Chain | Residue |
| A | TYR90 |
| B | HIS41 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG A 1297 |
| Chain | Residue |
| A | HIS41 |
| B | TYR90 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HG A 1298 |
| Chain | Residue |
| A | PHE67 |
| A | GLU153 |
| A | HIS154 |
| A | HOH2008 |
| A | HOH2063 |
| A | HOH2064 |
| A | HOH2147 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 1299 |
| Chain | Residue |
| A | TRP176 |
| A | HIS180 |
| A | ARG275 |
| B | GLU43 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 1300 |
| Chain | Residue |
| A | HIS117 |
| A | GLU196 |
| A | HOH2066 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 1301 |
| Chain | Residue |
| A | HIS117 |
| A | THR145 |
| A | SER149 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG A 1302 |
| Chain | Residue |
| A | PHE293 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG B 1299 |
| Chain | Residue |
| B | PHE293 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT A 1303 |
| Chain | Residue |
| A | GLY35 |
| A | THR36 |
| A | ARG37 |
| A | ARG38 |
| A | PHE207 |
| A | ARG209 |
| A | HOH2022 |
| A | HOH2027 |
| A | HOH2106 |
| A | HOH2149 |
| B | PRO257 |
| B | TYR259 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT B 1300 |
| Chain | Residue |
| A | PRO257 |
| A | TYR259 |
| A | HOH2134 |
| B | GLY35 |
| B | THR36 |
| B | ARG37 |
| B | ARG38 |
| B | PHE207 |
| B | ARG209 |
| B | HOH2016 |
| B | HOH2080 |
| B | HOH2097 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT A 1304 |
| Chain | Residue |
| A | ALA165 |
| A | LEU217 |
| A | HOH2082 |
| A | HOH2150 |
| A | HOH2151 |
| B | ALA165 |
| B | ALA166 |
| B | PRO216 |
| B | LEU217 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 954 |
| Chain | Residue | Details |
| A | ASP34 | metal ligand |
| A | ARG38 | proton acceptor, proton donor |
| A | TYR51 | proton acceptor, proton donor |
| A | TYR90 | activator, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 955 |
| Chain | Residue | Details |
| A | ASP34 | metal ligand |
| A | TYR51 | proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 954 |
| Chain | Residue | Details |
| B | ASP34 | metal ligand |
| B | ARG38 | proton acceptor, proton donor |
| B | TYR51 | proton acceptor, proton donor |
| B | TYR90 | activator, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 955 |
| Chain | Residue | Details |
| B | ASP34 | metal ligand |
| B | TYR51 | proton acceptor, proton donor |
