4CM2

Crystal structure of human soluble Adenylyl Cyclase soaked with bisulfite

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO3 A 1470

Chain	Residue
A	LYS95
A	LEU166
A	VAL167
A	PHE336
A	MET337

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG A 1471

Chain	Residue
A	SER153
A	GLY169
A	GLN170
A	TYR38
A	PHE39
A	HIS151
A	ILE152

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A 1472

Chain	Residue
A	TRP194
A	ARG199
A	ILE327

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1473

Chain	Residue
A	ILE24
A	VAL25
A	GLY27
A	HIS28
A	PHE29
A	LEU261
A	SER264
A	HOH2154

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1474

Chain	Residue
A	THR322
A	LEU325
A	LYS326
A	GLY330
A	GLN331
A	ILE332
A	HOH2106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00099

Chain	Residue	Details
A	ASP47
A	ILE48
A	ASP99

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24567411, ECO:0000269|PubMed:24616449, ECO:0007744|PDB:4CLL, ECO:0007744|PDB:4OYZ

Chain	Residue	Details
A	LYS95
A	VAL167
A	ARG176
A	MET337

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:25040695, ECO:0000305|PubMed:24567411, ECO:0000305|PubMed:24616449, ECO:0007744|PDB:4USW

Chain	Residue	Details
A	LYS144
A	VAL406

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:24567411, ECO:0000305|PubMed:24616449, ECO:0000305|PubMed:25040695

Chain	Residue	Details
A	ASN412

---