4CLW
Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate soaked with bisulfite
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE APC A 1467 |
| Chain | Residue |
| A | ASP47 |
| A | ARG176 |
| A | PHE336 |
| A | PHE338 |
| A | LEU345 |
| A | THR405 |
| A | VAL406 |
| A | VAL411 |
| A | ASN412 |
| A | ALA415 |
| A | ARG416 |
| A | ILE48 |
| A | CA1474 |
| A | HOH2027 |
| A | HOH2028 |
| A | HOH2057 |
| A | HOH2124 |
| A | HOH2134 |
| A | SER49 |
| A | GLY50 |
| A | PHE51 |
| A | THR52 |
| A | ALA97 |
| A | GLY98 |
| A | ASP99 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO3 A 1468 |
| Chain | Residue |
| A | LYS95 |
| A | LEU102 |
| A | LEU166 |
| A | VAL167 |
| A | VAL335 |
| A | MET337 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG A 1469 |
| Chain | Residue |
| A | HIS19 |
| A | LEU94 |
| A | LYS95 |
| A | PHE165 |
| A | TYR268 |
| A | GLU403 |
| A | EDO1470 |
| A | HOH2007 |
| A | HOH2066 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1470 |
| Chain | Residue |
| A | LYS95 |
| A | HIS164 |
| A | PHE165 |
| A | LYS334 |
| A | VAL335 |
| A | PEG1469 |
| A | HOH2066 |
| A | HOH2123 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1471 |
| Chain | Residue |
| A | HIS238 |
| A | LEU251 |
| A | PHE442 |
| A | LYS443 |
| A | GLU444 |
| A | GOL1475 |
| A | HOH2081 |
| A | HOH2146 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1472 |
| Chain | Residue |
| A | ASP357 |
| A | GLU358 |
| A | LEU359 |
| A | THR360 |
| A | GLY434 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1473 |
| Chain | Residue |
| A | THR322 |
| A | LYS326 |
| A | GLY330 |
| A | ILE332 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1474 |
| Chain | Residue |
| A | ASP47 |
| A | ILE48 |
| A | ASP99 |
| A | APC1467 |
| A | HOH2027 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1475 |
| Chain | Residue |
| A | TYR432 |
| A | ALA439 |
| A | GLU444 |
| A | EDO1471 |
| A | HOH2147 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 125 |
| Details | Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4USW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OYZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
