4CLU

Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1467

Chain	Residue
A	LYS95
A	VAL167
A	ACT1476
A	HOH2097

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1468

Chain	Residue
A	LYS95
A	LYS334
A	VAL335

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1469

Chain	Residue
A	GLY27
A	HIS28
A	PHE29
A	LEU261
A	SER264
A	HOH2133
A	ILE24
A	VAL25

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE POP A 1470

Chain	Residue
A	ASP47
A	ILE48
A	SER49
A	GLY50
A	PHE51
A	THR52
A	ASP99
A	LYS144
A	ASN412
A	MG1475
A	HOH2038

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1471

Chain	Residue
A	THR322
A	LEU325
A	GLN331
A	ILE332
A	HOH2202

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1472

Chain	Residue
A	PRO31
A	SER264
A	HOH2026
A	HOH2030
A	HOH2132

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1473

Chain	Residue
A	PHE58
A	TYR63
A	ASP65
A	GLY67
A	HOH2043
A	HOH2044
A	HOH2052

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1474

Chain	Residue
A	PRO356
A	ASP357
A	GLU358
A	LEU359
A	HOH2166

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1475

Chain	Residue
A	ASP47
A	ASP99
A	POP1470

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 1476

Chain	Residue
A	PHE45
A	LEU102
A	ARG176
A	PHE336
A	CL1467
A	HOH2102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	125
Details	Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4USW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---