4CLN
STRUCTURE OF A RECOMBINANT CALMODULIN FROM DROSOPHILA MELANOGASTER REFINED AT 2.2-ANGSTROMS RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005813 | cellular_component | centrosome |
| A | 0005814 | cellular_component | centriole |
| A | 0005819 | cellular_component | spindle |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005938 | cellular_component | cell cortex |
| A | 0007099 | biological_process | centriole replication |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0007608 | biological_process | sensory perception of smell |
| A | 0016028 | cellular_component | rhabdomere |
| A | 0016056 | biological_process | G protein-coupled opsin signaling pathway |
| A | 0016059 | biological_process | negative regulation of opsin-mediated signaling pathway |
| A | 0016060 | biological_process | negative regulation of phospholipase C-activating phototransduction signaling pathway |
| A | 0016247 | molecular_function | channel regulator activity |
| A | 0030048 | biological_process | actin filament-based movement |
| A | 0030234 | molecular_function | enzyme regulator activity |
| A | 0030496 | cellular_component | midbody |
| A | 0031475 | cellular_component | myosin V complex |
| A | 0031476 | cellular_component | myosin VI complex |
| A | 0031477 | cellular_component | myosin VII complex |
| A | 0031489 | molecular_function | myosin V binding |
| A | 0032036 | molecular_function | myosin heavy chain binding |
| A | 0042052 | biological_process | rhabdomere development |
| A | 0046716 | biological_process | muscle cell cellular homeostasis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048102 | biological_process | autophagic cell death |
| A | 0050911 | biological_process | detection of chemical stimulus involved in sensory perception of smell |
| A | 0051383 | biological_process | kinetochore organization |
| A | 0070855 | molecular_function | myosin VI head/neck binding |
| A | 0071361 | biological_process | cellular response to ethanol |
| A | 0072499 | biological_process | photoreceptor cell axon guidance |
| A | 0072686 | cellular_component | mitotic spindle |
| A | 0097431 | cellular_component | mitotic spindle pole |
Functional Information from PDB Data
| site_id | A |
| Number of Residues | 5 |
| Details |
| Chain | Residue |
| A | ASP20 |
| A | ASP22 |
| A | ASP24 |
| A | THR26 |
| A | GLU31 |
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 149 |
| Chain | Residue |
| A | ASP20 |
| A | ASP22 |
| A | ASP24 |
| A | THR26 |
| A | GLU31 |
| A | HOH153 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 150 |
| Chain | Residue |
| A | ASP56 |
| A | ASP58 |
| A | ASN60 |
| A | THR62 |
| A | GLU67 |
| A | HOH154 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 151 |
| Chain | Residue |
| A | ASP93 |
| A | ASP95 |
| A | ASN97 |
| A | PHE99 |
| A | GLU104 |
| A | HOH155 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 152 |
| Chain | Residue |
| A | ASP129 |
| A | ASP131 |
| A | ASP133 |
| A | GLN135 |
| A | GLU140 |
| A | HOH156 |
| site_id | B |
| Number of Residues | 5 |
| Details |
| Chain | Residue |
| A | GLU67 |
| A | ASP56 |
| A | ASP58 |
| A | ASN60 |
| A | THR62 |
| site_id | C |
| Number of Residues | 5 |
| Details |
| Chain | Residue |
| A | ASP93 |
| A | ASP95 |
| A | ASN97 |
| A | PHE99 |
| A | GLU104 |
| site_id | D |
| Number of Residues | 5 |
| Details |
| Chain | Residue |
| A | ASP129 |
| A | ASP131 |
| A | ASP133 |
| A | GLN135 |
| A | GLU140 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
| Chain | Residue | Details |
| A | ASP20-LEU32 | |
| A | ASP56-PHE68 | |
| A | ASP93-LEU105 | |
| A | ASP129-PHE141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| A | LYS21 | |
| A | PHE68 | |
| A | LYS94 | |
| A | GLY96 | |
| A | GLY98 | |
| A | LEU105 | |
| A | ILE130 | |
| A | GLY132 | |
| A | GLY134 | |
| A | VAL136 | |
| A | PHE141 | |
| A | GLY23 | |
| A | GLY25 | |
| A | ILE27 | |
| A | LEU32 | |
| A | ALA57 | |
| A | GLY59 | |
| A | GLY61 | |
| A | ILE63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Not N6-methylated |
| Chain | Residue | Details |
| A | LEU116 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:17610210 |
| Chain | Residue | Details |
| A | ASP95 |
