4CLL

Crystal structure of human soluble Adenylyl Cyclase in complex with bicarbonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCT A 1470

Chain	Residue
A	LYS95
A	LEU166
A	VAL167
A	VAL172
A	ARG176
A	PHE336
A	MET337

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1471

Chain	Residue
A	GLY98
A	ASP99
A	ALA100
A	GOL1481
A	PHE96
A	ALA97

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 1472

Chain	Residue
A	PHE58
A	SER59
A	SER60
A	ASP65
A	ARG66
A	GLY67
A	LEU289
A	HOH2061
A	HOH2062
A	HOH2068

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1473

Chain	Residue
A	GLN9
A	CME253
A	EDO1474

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1474

Chain	Residue
A	GLU7
A	CME253
A	EDO1473
A	HOH2007
A	HOH2281
A	HOH2318

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1475

Chain	Residue
A	PRO191
A	TRP194
A	GLN195
A	ARG211

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1476

Chain	Residue
A	LEU255
A	LYS256
A	ASP258
A	LEU261
A	HOH2192

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1477

Chain	Residue
A	TYR38
A	PHE39
A	HIS151
A	ILE152
A	SER153
A	HOH2145

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1478

Chain	Residue
A	ARG109
A	GLY150
A	HIS151
A	ASN192
A	HOH2125

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1479

Chain	Residue
A	HOH2319

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1480

Chain	Residue
A	GLY389
A	ILE390
A	GLN409
A	HOH2277

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1481

Chain	Residue
A	GLY98
A	ASP99
A	ASN333
A	LYS334
A	LEU345
A	THR405
A	VAL406
A	EDO1471

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1482

Chain	Residue
A	THR322
A	LEU325
A	LYS326
A	GLY330
A	GLN331
A	ILE332
A	HOH2140
A	HOH2250

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1483

Chain	Residue
A	GLU288
A	ARG290
A	GLY349

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	125
Details	Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4USW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---