4CHV
The electron crystallography structure of the cAMP-bound potassium channel MloK1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005221 | molecular_function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
A | 0005267 | molecular_function | potassium channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0030552 | molecular_function | cAMP binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0044877 | molecular_function | protein-containing complex binding |
A | 0055085 | biological_process | transmembrane transport |
A | 0071805 | biological_process | potassium ion transmembrane transport |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005221 | molecular_function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
B | 0005267 | molecular_function | potassium channel activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0030552 | molecular_function | cAMP binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0044877 | molecular_function | protein-containing complex binding |
B | 0055085 | biological_process | transmembrane transport |
B | 0071805 | biological_process | potassium ion transmembrane transport |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005221 | molecular_function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
C | 0005267 | molecular_function | potassium channel activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0030552 | molecular_function | cAMP binding |
C | 0042802 | molecular_function | identical protein binding |
C | 0044877 | molecular_function | protein-containing complex binding |
C | 0055085 | biological_process | transmembrane transport |
C | 0071805 | biological_process | potassium ion transmembrane transport |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005221 | molecular_function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
D | 0005267 | molecular_function | potassium channel activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0030552 | molecular_function | cAMP binding |
D | 0042802 | molecular_function | identical protein binding |
D | 0044877 | molecular_function | protein-containing complex binding |
D | 0055085 | biological_process | transmembrane transport |
D | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE K B 1350 |
Chain | Residue |
A | GLY177 |
A | TYR178 |
B | GLY177 |
B | TYR178 |
C | GLY177 |
C | TYR178 |
D | GLY177 |
D | TYR178 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE K A 1350 |
Chain | Residue |
A | THR176 |
B | THR175 |
B | THR176 |
C | THR175 |
C | THR176 |
D | THR175 |
D | THR176 |
A | THR175 |
Functional Information from PROSITE/UniProt
site_id | PS00888 |
Number of Residues | 17 |
Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICrIGEpGDrMFFVveG |
Chain | Residue | Details |
A | ILE262-GLY278 |
site_id | PS00889 |
Number of Residues | 18 |
Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEmALisgep......RSAtVsA |
Chain | Residue | Details |
A | PHE296-ALA313 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 732 |
Details | TOPO_DOM: Cytoplasmic |
Chain | Residue | Details |
A | MET1-PRO12 | |
C | LYS62-LYS74 | |
C | THR113-LEU129 | |
C | ALA211-ALA355 | |
D | MET1-PRO12 | |
D | LYS62-LYS74 | |
D | THR113-LEU129 | |
D | ALA211-ALA355 | |
A | LYS62-LYS74 | |
A | THR113-LEU129 | |
A | ALA211-ALA355 | |
B | MET1-PRO12 | |
B | LYS62-LYS74 | |
B | THR113-LEU129 | |
B | ALA211-ALA355 | |
C | MET1-PRO12 |
site_id | SWS_FT_FI2 |
Number of Residues | 68 |
Details | TRANSMEM: Helical; Name=Segment S1 |
Chain | Residue | Details |
A | LEU13-ILE30 | |
B | LEU13-ILE30 | |
C | LEU13-ILE30 | |
D | LEU13-ILE30 |
site_id | SWS_FT_FI3 |
Number of Residues | 84 |
Details | TOPO_DOM: Periplasmic |
Chain | Residue | Details |
A | PRO31-ARG38 | |
D | PRO31-ARG38 | |
D | GLU151-SER161 | |
D | THR181-SER185 | |
A | GLU151-SER161 | |
A | THR181-SER185 | |
B | PRO31-ARG38 | |
B | GLU151-SER161 | |
B | THR181-SER185 | |
C | PRO31-ARG38 | |
C | GLU151-SER161 | |
C | THR181-SER185 |
site_id | SWS_FT_FI4 |
Number of Residues | 88 |
Details | TRANSMEM: Helical; Name=Segment S2 |
Chain | Residue | Details |
A | LEU39-LEU61 | |
B | LEU39-LEU61 | |
C | LEU39-LEU61 | |
D | LEU39-LEU61 |
site_id | SWS_FT_FI5 |
Number of Residues | 76 |
Details | TRANSMEM: Helical; Name=Segment S3 |
Chain | Residue | Details |
A | ILE75-SER94 | |
B | ILE75-SER94 | |
C | ILE75-SER94 | |
D | ILE75-SER94 |
site_id | SWS_FT_FI6 |
Number of Residues | 68 |
Details | TRANSMEM: Helical; Name=Segment S4 |
Chain | Residue | Details |
A | PRO95-SER112 | |
B | PRO95-SER112 | |
C | PRO95-SER112 | |
D | PRO95-SER112 |
site_id | SWS_FT_FI7 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=Segment S5 |
Chain | Residue | Details |
A | ILE130-ILE150 | |
B | ILE130-ILE150 | |
C | ILE130-ILE150 | |
D | ILE130-ILE150 |
site_id | SWS_FT_FI8 |
Number of Residues | 72 |
Details | INTRAMEM: Pore-forming |
Chain | Residue | Details |
A | ILE162-ASP180 | |
B | ILE162-ASP180 | |
C | ILE162-ASP180 | |
D | ILE162-ASP180 |
site_id | SWS_FT_FI9 |
Number of Residues | 96 |
Details | TRANSMEM: Helical; Name=Segment S6 |
Chain | Residue | Details |
A | PHE186-LEU210 | |
B | PHE186-LEU210 | |
C | PHE186-LEU210 | |
D | PHE186-LEU210 |
site_id | SWS_FT_FI10 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0007744|PDB:1VP6 |
Chain | Residue | Details |
A | GLY297 | |
D | GLY297 | |
D | ARG307 | |
D | ARG348 | |
A | ARG307 | |
A | ARG348 | |
B | GLY297 | |
B | ARG307 | |
B | ARG348 | |
C | GLY297 | |
C | ARG307 | |
C | ARG348 |