4CHT

Crystal structure of the human topoisomerase III alpha-RMI1 complex with bound calcium ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003916	molecular_function	DNA topoisomerase activity
A	0003917	molecular_function	DNA topoisomerase type I (single strand cut, ATP-independent) activity
A	0005694	cellular_component	chromosome
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1640

Chain	Residue
A	GLU41
A	HOH2001
A	HOH2002
A	HOH2003
A	HOH2004
A	HOH2005

---

Functional Information from PROSITE/UniProt

site_id	PS00396
Number of Residues	15
Details	TOPO_IA_1 Topoisomerase (Topo) IA-type active site signature. EkLYTqgy.........ISYpRTE

Chain	Residue	Details
A	GLU352-GLU366

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Domain: {"description":"Toprim","evidences":[{"source":"PROSITE-ProRule","id":"PRU00995","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	420
Details	Domain: {"description":"Topo IA-type catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---