4CH9
Crystal structure of the human KLHL3 Kelch domain in complex with a WNK4 peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1586 |
| Chain | Residue |
| A | ARG362 |
| A | ARG383 |
| A | HOH2297 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1587 |
| Chain | Residue |
| C | ASP564 |
| A | SER433 |
| A | SER481 |
| A | HIS498 |
| A | ARG528 |
| A | ASN529 |
| A | TYR577 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1588 |
| Chain | Residue |
| A | ARG339 |
| A | ARG360 |
| A | SER385 |
| A | HOH2083 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1586 |
| Chain | Residue |
| B | ARG362 |
| B | ARG383 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1587 |
| Chain | Residue |
| A | LYS417 |
| B | SER335 |
| B | ARG337 |
| B | ASN356 |
| B | HOH2038 |
| B | HOH2260 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1588 |
| Chain | Residue |
| B | ARG337 |
| B | ALA351 |
| B | GLY353 |
| B | VAL361 |
| B | THR363 |
| B | ASP365 |
| B | HOH2037 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1589 |
| Chain | Residue |
| B | ARG339 |
| B | ARG360 |
| B | SER385 |
| B | HOH2087 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 96 |
| Details | Repeat: {"description":"Kelch 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"26435498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"26435498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA and PKC","evidences":[{"source":"PubMed","id":"25313067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26435498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27727489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30718414","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
