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4CH9

Crystal structure of the human KLHL3 Kelch domain in complex with a WNK4 peptide

Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1586
ChainResidue
AARG362
AARG383
AHOH2297

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 1587
ChainResidue
CASP564
ASER433
ASER481
AHIS498
AARG528
AASN529
ATYR577

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 1588
ChainResidue
AARG339
AARG360
ASER385
AHOH2083

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B 1586
ChainResidue
BARG362
BARG383

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 1587
ChainResidue
ALYS417
BSER335
BARG337
BASN356
BHOH2038
BHOH2260

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO B 1588
ChainResidue
BARG337
BALA351
BGLY353
BVAL361
BTHR363
BASP365
BHOH2037

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B 1589
ChainResidue
BARG339
BARG360
BSER385
BHOH2087

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:26435498
ChainResidueDetails
ATHR375
BTHR375

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:26435498
ChainResidueDetails
ASER376
BSER376

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA and PKC => ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:26435498, ECO:0000269|PubMed:27727489, ECO:0000269|PubMed:30718414
ChainResidueDetails
ASER433
BSER433

227111

PDB entries from 2024-11-06

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