4CGO
Leishmania major N-myristoyltransferase in complex with a thienopyrimidine inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006499 | biological_process | N-terminal protein myristoylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0072657 | biological_process | protein localization to membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1000 |
| Chain | Residue |
| A | LEU175 |
| A | GLU177 |
| A | LYS178 |
| A | ARG179 |
| A | LEU180 |
| A | MYA1001 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE MYA A 1001 |
| Chain | Residue |
| A | TRP15 |
| A | ASN79 |
| A | TYR80 |
| A | VAL81 |
| A | PHE168 |
| A | LEU169 |
| A | CYS170 |
| A | VAL171 |
| A | ARG176 |
| A | GLU177 |
| A | LYS178 |
| A | ARG179 |
| A | LEU180 |
| A | ALA181 |
| A | PRO182 |
| A | THR189 |
| A | VAL192 |
| A | TRP198 |
| A | TYR202 |
| A | THR203 |
| A | LEU208 |
| A | TYR404 |
| A | MG1000 |
| A | HOH2001 |
| A | HOH2002 |
| A | HOH2345 |
| A | HOH2351 |
| A | HOH2569 |
| A | HOH2570 |
| A | HOH2571 |
| A | HOH2572 |
| A | HOH2573 |
| A | HOH2574 |
| A | HIS12 |
| A | ALA13 |
| A | PHE14 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 6KV A 1422 |
| Chain | Residue |
| A | PHE90 |
| A | TYR92 |
| A | ASN167 |
| A | THR203 |
| A | GLY205 |
| A | TYR217 |
| A | HIS219 |
| A | TYR345 |
| A | HIS398 |
| A | LEU421 |
| A | 6KV1423 |
| A | HOH2190 |
| A | HOH2368 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 6KV A 1423 |
| Chain | Residue |
| A | VAL81 |
| A | GLU82 |
| A | ASP83 |
| A | PHE88 |
| A | PHE90 |
| A | PHE232 |
| A | SER330 |
| A | LEU341 |
| A | ALA343 |
| A | ASN376 |
| A | ASP396 |
| A | 6KV1422 |
Functional Information from PROSITE/UniProt
