4CEJ
Crystal structure of AddAB-DNA-ADPNP complex at 3 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000724 | biological_process | double-strand break repair via homologous recombination |
| A | 0000725 | biological_process | recombinational repair |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003678 | molecular_function | DNA helicase activity |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006281 | biological_process | DNA repair |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0032508 | biological_process | DNA duplex unwinding |
| A | 0033202 | cellular_component | DNA helicase complex |
| A | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| B | 0000724 | biological_process | double-strand break repair via homologous recombination |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003690 | molecular_function | double-stranded DNA binding |
| B | 0004386 | molecular_function | helicase activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006281 | biological_process | DNA repair |
| B | 0006310 | biological_process | DNA recombination |
| B | 0008409 | molecular_function | 5'-3' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ANP A 2233 |
| Chain | Residue |
| A | THR10 |
| A | ALA38 |
| A | GLN441 |
| A | PHE478 |
| A | ARG479 |
| A | LYS573 |
| A | GLU800 |
| A | ARG873 |
| A | HOH2001 |
| A | HOH2002 |
| A | HOH2003 |
| A | GLN15 |
| A | MG2234 |
| A | ALA31 |
| A | ALA32 |
| A | GLY33 |
| A | SER34 |
| A | GLY35 |
| A | LYS36 |
| A | THR37 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2234 |
| Chain | Residue |
| A | THR37 |
| A | HOH2001 |
| A | HOH2002 |
| A | HOH2003 |
| A | ANP2233 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SF4 B 2160 |
| Chain | Residue |
| B | CYS801 |
| B | PRO1112 |
| B | CYS1121 |
| B | CYS1124 |
| B | CYS1130 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ANP B 2161 |
| Chain | Residue |
| B | SER10 |
| B | GLY11 |
| B | SER12 |
| B | GLY13 |
| B | LYS14 |
| B | THR15 |
| B | LYS16 |
| B | THR236 |
| B | GLU282 |
| B | ARG283 |
| B | GLY600 |
| B | MET656 |
| B | HOH2001 |
| B | HOH2002 |
| B | MG2162 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 2162 |
| Chain | Residue |
| B | THR15 |
| B | ASP208 |
| B | HOH2001 |
| B | HOH2002 |
| B | HOH2003 |
| B | ANP2161 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000312|PDB:4CEI, ECO:0000312|PDB:4CEJ |
| Chain | Residue | Details |
| B | SER10 | |
| B | GLY11 | |
| B | LYS16 | |
| B | THR236 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:24670664, ECO:0000312|PDB:4CEI, ECO:0000312|PDB:4CEJ |
| Chain | Residue | Details |
| B | LYS14 | |
| B | THR15 | |
| B | ARG283 | |
| A | ARG479 | |
| A | ARG873 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01452, ECO:0000269|PubMed:22307084, ECO:0000269|PubMed:24670664, ECO:0007744|PDB:3U44, ECO:0007744|PDB:4CEH, ECO:0007744|PDB:4CEI, ECO:0007744|PDB:4CEJ |
| Chain | Residue | Details |
| B | CYS801 | |
| B | CYS1121 | |
| B | CYS1124 | |
| B | CYS1130 |
