4CEJ

Crystal structure of AddAB-DNA-ADPNP complex at 3 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000725	biological_process	recombinational repair
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003690	molecular_function	double-stranded DNA binding
A	0004386	molecular_function	helicase activity
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006974	biological_process	DNA damage response
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0032508	biological_process	DNA duplex unwinding
A	0033202	cellular_component	DNA helicase complex
A	0043138	molecular_function	3'-5' DNA helicase activity
B	0000166	molecular_function	nucleotide binding
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003690	molecular_function	double-stranded DNA binding
B	0004386	molecular_function	helicase activity
B	0004518	molecular_function	nuclease activity
B	0004527	molecular_function	exonuclease activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006281	biological_process	DNA repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0008409	molecular_function	5'-3' exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0032508	biological_process	DNA duplex unwinding
B	0046872	molecular_function	metal ion binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ANP A 2233

Chain	Residue
A	THR10
A	ALA38
A	GLN441
A	PHE478
A	ARG479
A	LYS573
A	GLU800
A	ARG873
A	HOH2001
A	HOH2002
A	HOH2003
A	GLN15
A	MG2234
A	ALA31
A	ALA32
A	GLY33
A	SER34
A	GLY35
A	LYS36
A	THR37

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 2234

Chain	Residue
A	THR37
A	HOH2001
A	HOH2002
A	HOH2003
A	ANP2233

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SF4 B 2160

Chain	Residue
B	CYS801
B	PRO1112
B	CYS1121
B	CYS1124
B	CYS1130

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP B 2161

Chain	Residue
B	SER10
B	GLY11
B	SER12
B	GLY13
B	LYS14
B	THR15
B	LYS16
B	THR236
B	GLU282
B	ARG283
B	GLY600
B	MET656
B	HOH2001
B	HOH2002
B	MG2162

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 2162

Chain	Residue
B	THR15
B	ASP208
B	HOH2001
B	HOH2002
B	HOH2003
B	ANP2161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000312|PDB:4CEI, ECO:0000312|PDB:4CEJ

Chain	Residue	Details
B	SER10
B	GLY11
B	LYS16
B	THR236

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:24670664, ECO:0000312|PDB:4CEI, ECO:0000312|PDB:4CEJ

Chain	Residue	Details
A	ARG873
B	LYS14
B	THR15
B	ARG283
A	ARG479

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01452, ECO:0000269|PubMed:22307084, ECO:0000269|PubMed:24670664, ECO:0007744|PDB:3U44, ECO:0007744|PDB:4CEH, ECO:0007744|PDB:4CEI, ECO:0007744|PDB:4CEJ

Chain	Residue	Details
B	CYS801
B	CYS1121
B	CYS1124
B	CYS1130

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