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4CAX

Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand (DDD85646)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004379molecular_functionglycylpeptide N-tetradecanoyltransferase activity
A0006499biological_processN-terminal protein myristoylation
Functional Information from PDB Data
site_idAC1
Number of Residues30
DetailsBINDING SITE FOR RESIDUE MYA A 1493
ChainResidue
AHIS146
ALYS224
AARG225
ALEU226
ATHR227
APRO228
AILE231
ATHR235
ATYR244
ATYR248
ATHR249
ATYR147
ALEU254
ATYR462
AHOH2143
AHOH2146
AHOH2291
AHOH2292
AHOH2293
AHOH2294
AHOH2295
AHOH2296
AVAL148
AHOH2298
APHE214
ALEU215
ACYS216
AILE217
AARG222
ASER223

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 646 A 1494
ChainResidue
AVAL148
AASP150
APHE155
APHE157
ATHR249
AGLY251
ATYR263
AHIS265
APHE278
ASER378
ATYR393
AGLN456
ALEU457
ALEU492
AHOH2074
AHOH2140
AHOH2174
AHOH2299

Functional Information from PROSITE/UniProt
site_idPS00975
Number of Residues9
DetailsNMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCiHK
ChainResidueDetails
AGLU211-LYS219

site_idPS00976
Number of Residues7
DetailsNMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGaGDG
ChainResidueDetails
ALYS449-GLY455

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor; via carboxylate => ECO:0000250
ChainResidueDetails
ALEU492

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P14743
ChainResidueDetails
ALEU215
ASER223

222926

PDB entries from 2024-07-24

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