4C82

IspF (Plasmodium falciparum) unliganded structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 1240

Chain	Residue
A	ASP71
A	HIS73
A	HIS123

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1241

Chain	Residue
A	TYR70
A	HIS215
A	GLU228
A	HOH2088

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1242

Chain	Residue
A	VAL220
A	VAL220
A	VAL220
A	GLY219
A	GLY219

---

Functional Information from PROSITE/UniProt

site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDIIyHSivDSilG

Chain	Residue	Details
A	SER116-GLY131

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:24410837, ECO:0007744|PDB:4C81, ECO:0007744|PDB:4C82

Chain	Residue	Details
A	ASP71
A	HIS73
A	HIS123

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P62617

Chain	Residue	Details
A	HIS115
A	PHE142

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:24410837, ECO:0007744|PDB:4C81

Chain	Residue	Details
A	ASP137
A	ALA181
A	GLY212

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P62617

Chain	Residue	Details
A	HIS115
A	THR214

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