4C7B
Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1394 |
| Chain | Residue |
| A | CYS256 |
| A | CYS259 |
| A | CYS280 |
| A | CYS283 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BVB A 1395 |
| Chain | Residue |
| A | ASP231 |
| A | ALA146 |
| A | PHE157 |
| A | LEU173 |
| A | GLN228 |
| A | ASN229 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA A 1396 |
| Chain | Residue |
| A | GLN300 |
| A | GLN300 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1397 |
| Chain | Residue |
| A | GLU177 |
| A | GLU181 |
| A | PHE294 |
| A | HOH2134 |
| B | ARG1 |
| B | LYS3 |
| B | FDL4 |
| B | HOH2001 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1398 |
| Chain | Residue |
| A | LEU298 |
| A | PRO299 |
| A | GLN300 |
| A | HOH2096 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1399 |
| Chain | Residue |
| A | THR255 |
| A | LYS288 |
| A | PRO289 |
| A | ASP290 |
| A | ILE291 |
| A | VAL292 |
| A | GLU296 |
| A | HOH2075 |
| A | HOH2095 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:36896611 |
| Chain | Residue | Details |
| A | HIS248 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23897466 |
| Chain | Residue | Details |
| A | GLY145 | |
| A | GLN228 | |
| A | GLY319 | |
| A | ASN344 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466, ECO:0000269|PubMed:36896611, ECO:0000269|PubMed:37720100 |
| Chain | Residue | Details |
| A | CYS256 | |
| A | CYS259 | |
| A | CYS283 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466, ECO:0000269|PubMed:36896611 |
| Chain | Residue | Details |
| A | CYS280 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R104 |
| Chain | Residue | Details |
| A | LYS122 |
