4C7B

Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1394

Chain	Residue
A	CYS256
A	CYS259
A	CYS280
A	CYS283

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BVB A 1395

Chain	Residue
A	ASP231
A	ALA146
A	PHE157
A	LEU173
A	GLN228
A	ASN229

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IPA A 1396

Chain	Residue
A	GLN300
A	GLN300

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1397

Chain	Residue
A	GLU177
A	GLU181
A	PHE294
A	HOH2134
B	ARG1
B	LYS3
B	FDL4
B	HOH2001

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1398

Chain	Residue
A	LEU298
A	PRO299
A	GLN300
A	HOH2096

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1399

Chain	Residue
A	THR255
A	LYS288
A	PRO289
A	ASP290
A	ILE291
A	VAL292
A	GLU296
A	HOH2075
A	HOH2095

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16788062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18794531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37720100","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R104","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---