4C6G

Structural Investigations into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus chinensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0006558	biological_process	L-phenylalanine metabolic process
A	0006559	biological_process	L-phenylalanine catabolic process
A	0009698	biological_process	phenylpropanoid metabolic process
A	0009800	biological_process	cinnamic acid biosynthetic process
A	0009820	biological_process	alkaloid metabolic process
A	0009821	biological_process	alkaloid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016841	molecular_function	ammonia-lyase activity
A	0016853	molecular_function	isomerase activity
A	0016869	molecular_function	intramolecular aminotransferase activity
A	0042617	biological_process	paclitaxel biosynthetic process
A	0045548	molecular_function	phenylalanine ammonia-lyase activity
A	0051289	biological_process	protein homotetramerization
B	0003824	molecular_function	catalytic activity
B	0005737	cellular_component	cytoplasm
B	0006558	biological_process	L-phenylalanine metabolic process
B	0006559	biological_process	L-phenylalanine catabolic process
B	0009698	biological_process	phenylpropanoid metabolic process
B	0009800	biological_process	cinnamic acid biosynthetic process
B	0009820	biological_process	alkaloid metabolic process
B	0009821	biological_process	alkaloid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016841	molecular_function	ammonia-lyase activity
B	0016853	molecular_function	isomerase activity
B	0016869	molecular_function	intramolecular aminotransferase activity
B	0042617	biological_process	paclitaxel biosynthetic process
B	0045548	molecular_function	phenylalanine ammonia-lyase activity
B	0051289	biological_process	protein homotetramerization
C	0003824	molecular_function	catalytic activity
C	0005737	cellular_component	cytoplasm
C	0006558	biological_process	L-phenylalanine metabolic process
C	0006559	biological_process	L-phenylalanine catabolic process
C	0009698	biological_process	phenylpropanoid metabolic process
C	0009800	biological_process	cinnamic acid biosynthetic process
C	0009820	biological_process	alkaloid metabolic process
C	0009821	biological_process	alkaloid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016841	molecular_function	ammonia-lyase activity
C	0016853	molecular_function	isomerase activity
C	0016869	molecular_function	intramolecular aminotransferase activity
C	0042617	biological_process	paclitaxel biosynthetic process
C	0045548	molecular_function	phenylalanine ammonia-lyase activity
C	0051289	biological_process	protein homotetramerization
D	0003824	molecular_function	catalytic activity
D	0005737	cellular_component	cytoplasm
D	0006558	biological_process	L-phenylalanine metabolic process
D	0006559	biological_process	L-phenylalanine catabolic process
D	0009698	biological_process	phenylpropanoid metabolic process
D	0009800	biological_process	cinnamic acid biosynthetic process
D	0009820	biological_process	alkaloid metabolic process
D	0009821	biological_process	alkaloid biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016841	molecular_function	ammonia-lyase activity
D	0016853	molecular_function	isomerase activity
D	0016869	molecular_function	intramolecular aminotransferase activity
D	0042617	biological_process	paclitaxel biosynthetic process
D	0045548	molecular_function	phenylalanine ammonia-lyase activity
D	0051289	biological_process	protein homotetramerization

Functional Information from PROSITE/UniProt

site_id	PS00488
Number of Residues	17
Details	PAL_HISTIDASE Phenylalanine and histidine ammonia-lyases signature. GSVSASGDLiPLAyiaG

Chain	Residue	Details
A	GLY171-GLY187

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22113970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24786474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24786474","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CQ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P11544","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"2,3-didehydroalanine (Ser)","evidences":[{"source":"PubMed","id":"24786474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Cross-link: {"description":"5-imidazolinone (Ala-Gly)","evidences":[{"source":"PubMed","id":"24786474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---