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4C6B

Crystal structure of the dihydroorotase domain of human CAD with incomplete active site, obtained recombinantly from E. coli.

Functional Information from GO Data
ChainGOidnamespacecontents
A0016787molecular_functionhydrolase activity
A0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE FMT A 2824
ChainResidue
APRO1586
AILE1587
AARG1608
ASER1609
AVAL1610
AHIS1611
AHOH2155
AHOH2186

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE FMT A 2825
ChainResidue
AHIS1734
AARG1737
AARG1737
AHIS1734

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT A 2826
ChainResidue
AHIS1584
AGLN1819
ALEU1820
AHOH2138
AHOH2232
AHOH2301

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE FMT A 2827
ChainResidue
AGLN1604
ALEU1605
AARG1630
AHOH2179

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT A 2828
ChainResidue
ASER1539
AGLU1540
AALA1542
AHOH2096
AHOH2099
AHOH2123

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 2829
ChainResidue
AGLN1807
ATRP1812
AGLN1814
AHOH2291

Functional Information from PROSITE/UniProt
site_idPS00482
Number of Residues9
DetailsDIHYDROOROTASE_1 Dihydroorotase signature 1. DVHVHLReP
ChainResidueDetails
AASP1469-PRO1477

site_idPS00483
Number of Residues12
DetailsDIHYDROOROTASE_2 Dihydroorotase signature 2. ASDhAPHtleeK
ChainResidueDetails
AALA1684-LYS1695

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"For DHOase activity","evidences":[{"source":"UniProtKB","id":"P05020","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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