4C5M
Structure of the pyridoxal kinase from Staphylococcus aureus in complex with AMP-PCP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
| A | 0009228 | biological_process | thiamine biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
| B | 0009228 | biological_process | thiamine biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
| C | 0009228 | biological_process | thiamine biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
| D | 0009228 | biological_process | thiamine biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ACP A 500 |
| Chain | Residue |
| A | ASN139 |
| A | GLN205 |
| A | ASN209 |
| A | GLY213 |
| A | LYS238 |
| A | ILE245 |
| A | SO41280 |
| A | HOH2161 |
| A | HOH2162 |
| A | HOH2164 |
| A | HOH2165 |
| A | LYS176 |
| A | HOH2185 |
| A | HOH2194 |
| A | GLY178 |
| A | LYS179 |
| A | SER186 |
| A | ASP188 |
| A | ASP202 |
| A | MET203 |
| A | PHE204 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ACP B 500 |
| Chain | Residue |
| B | ASN139 |
| B | LYS176 |
| B | GLY178 |
| B | LYS179 |
| B | SER186 |
| B | ASP188 |
| B | ASP202 |
| B | MET203 |
| B | PHE204 |
| B | GLN205 |
| B | ASN209 |
| B | GLY213 |
| B | LYS238 |
| B | ILE245 |
| B | HOH2151 |
| B | HOH2152 |
| B | HOH2154 |
| B | HOH2177 |
| B | HOH2181 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ACP C 500 |
| Chain | Residue |
| C | ASN139 |
| C | LYS176 |
| C | LYS179 |
| C | SER186 |
| C | ASP188 |
| C | ASP202 |
| C | MET203 |
| C | PHE204 |
| C | GLN205 |
| C | ASN209 |
| C | GLY213 |
| C | LYS238 |
| C | ILE245 |
| C | HOH2102 |
| C | HOH2103 |
| C | HOH2131 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ACP D 500 |
| Chain | Residue |
| D | LYS176 |
| D | GLY178 |
| D | LYS179 |
| D | SER186 |
| D | ASP188 |
| D | ASP202 |
| D | MET203 |
| D | PHE204 |
| D | GLN205 |
| D | ASN209 |
| D | GLY213 |
| D | LYS238 |
| D | ILE245 |
| D | SO41280 |
| D | HOH2128 |
| D | HOH2129 |
| D | HOH2152 |
| D | HOH2167 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1277 |
| Chain | Residue |
| B | GLN205 |
| B | GLN206 |
| B | SER207 |
| B | HOH2192 |
| B | HOH2247 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1278 |
| Chain | Residue |
| B | TYR208 |
| B | LYS250 |
| B | HOH2159 |
| B | HOH2160 |
| B | HOH2248 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1277 |
| Chain | Residue |
| A | HOH2273 |
| D | GLN205 |
| D | GLN206 |
| D | SER207 |
| D | HOH2250 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1277 |
| Chain | Residue |
| C | TYR208 |
| C | LYS250 |
| C | HOH2199 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1278 |
| Chain | Residue |
| C | GLN205 |
| C | GLN206 |
| C | SER207 |
| C | HOH2144 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1277 |
| Chain | Residue |
| A | GLY72 |
| A | ASN98 |
| A | HOH2107 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1278 |
| Chain | Residue |
| A | GLN205 |
| A | GLN206 |
| A | SER207 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1279 |
| Chain | Residue |
| A | HIS210 |
| A | VAL255 |
| A | SO41280 |
| A | HOH2218 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1279 |
| Chain | Residue |
| B | TYR223 |
| B | LYS228 |
| B | TYR263 |
| B | HOH2205 |
| B | HOH2235 |
| B | HOH2249 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1280 |
| Chain | Residue |
| B | LYS5 |
| B | ASN98 |
| B | HOH2010 |
| B | HOH2097 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1278 |
| Chain | Residue |
| D | LYS5 |
| D | GLY72 |
| D | ASN98 |
| D | HOH2004 |
| D | HOH2073 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1279 |
| Chain | Residue |
| C | PRO57 |
| C | MET58 |
| C | HOH2042 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1279 |
| Chain | Residue |
| A | HIS268 |
| A | HOH2267 |
| D | THR83 |
| D | GLU84 |
| D | ASN121 |
| D | HOH2083 |
| site_id | BC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1280 |
| Chain | Residue |
| D | HIS210 |
| D | GLY211 |
| D | ALA212 |
| D | GLY213 |
| D | CYS214 |
| D | ACP500 |
| D | HOH2193 |
| D | HOH2252 |
| D | HOH2254 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1280 |
| Chain | Residue |
| A | HIS210 |
| A | GLY211 |
| A | ALA212 |
| A | GLY213 |
| A | CYS214 |
| A | ACP500 |
| A | SO41279 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1281 |
| Chain | Residue |
| D | LYS185 |
| D | TYR187 |
| D | HOH2165 |
| D | HOH2179 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1280 |
| Chain | Residue |
| C | GLY72 |
| C | ASN98 |
| C | HOH2009 |
| C | HOH2055 |
