4C4Y
Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with A4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 7WI A 1548 |
| Chain | Residue |
| A | PHE267 |
| A | TRP525 |
| A | ASP335 |
| A | TRP336 |
| A | MET339 |
| A | TYR383 |
| A | PHE387 |
| A | LEU408 |
| A | TYR466 |
| A | HIS524 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 |
| Chain | Residue | Details |
| A | ASP335 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 |
| Chain | Residue | Details |
| A | TYR466 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 |
| Chain | Residue | Details |
| A | HIS524 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 |
| Chain | Residue | Details |
| A | TYR383 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P34914 |
| Chain | Residue | Details |
| A | SER370 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P34914 |
| Chain | Residue | Details |
| A | LYS421 | |
| A | LYS455 | |
| A | LYS554 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | LIPID: S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine => ECO:0000305|PubMed:21164107 |
| Chain | Residue | Details |
| A | CYS522 |
