4C3U

Extensive counter-ion interactions with subtilisin in aqueous medium, Cs derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1276

Chain	Residue
A	GLN2
A	SER184
A	ASN185

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1277

Chain	Residue
A	ASN240
A	GLN245

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1291

Chain	Residue
A	LYS170

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1278

Chain	Residue
A	ASN158

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1292

Chain	Residue
A	SER99
A	ASN248

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1293

Chain	Residue
A	ALA194

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS A 1279

Chain	Residue
A	ALA37
A	HIS39
A	LEU42

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CS A 1280

Chain	Residue
A	GLY193
A	ALA194
A	LEU196
A	SER260

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS A 1281

Chain	Residue
A	GLY61
A	SER98
A	HOH2042

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS A 1282

Chain	Residue
A	ALA52
A	TYR256
A	HOH2025

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 1283

Chain	Residue
A	TYR143
A	HOH2066

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CS A 1284

Chain	Residue
A	PRO239
A	LEU241
A	HOH2058
A	HOH2068

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CS A 1285

Chain	Residue
A	ALA1
A	THR3
A	GLY80
A	HOH2001
A	HOH2093

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 1286

Chain	Residue
A	SER156
A	ASN158

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CS A 1287

Chain	Residue
A	GLY47

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 1288

Chain	Residue
A	SER159
A	THR162

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1289

Chain	Residue
A	GLN2
A	ASP41
A	LEU75
A	ASN77
A	THR79
A	VAL81

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1290

Chain	Residue
A	ALA169
A	TYR171
A	VAL174
A	HOH2078
A	HOH2081

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VAVLDTGIqasH

Chain	Residue	Details
A	VAL28-HIS39

---

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVAGtVAA

Chain	Residue	Details
A	HIS64-ALA74

---

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAsPhVAG

Chain	Residue	Details
A	GLY219-GLY229

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	268
Details	Domain: {"description":"Peptidase S8","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8512925","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---