4C21
L-Fucose Isomerase In Complex With Fucitol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005996 | biological_process | monosaccharide metabolic process |
| A | 0006004 | biological_process | fucose metabolic process |
| A | 0008736 | molecular_function | L-fucose isomerase activity |
| A | 0008790 | molecular_function | arabinose isomerase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| A | 0019317 | biological_process | fucose catabolic process |
| A | 0019571 | biological_process | D-arabinose catabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0042355 | biological_process | L-fucose catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005996 | biological_process | monosaccharide metabolic process |
| B | 0006004 | biological_process | fucose metabolic process |
| B | 0008736 | molecular_function | L-fucose isomerase activity |
| B | 0008790 | molecular_function | arabinose isomerase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| B | 0019317 | biological_process | fucose catabolic process |
| B | 0019571 | biological_process | D-arabinose catabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0042355 | biological_process | L-fucose catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 600 |
| Chain | Residue |
| A | GLU335 |
| A | ASP359 |
| A | ASN390 |
| A | SER391 |
| A | HIS525 |
| A | FOC601 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FOC A 601 |
| Chain | Residue |
| A | MET183 |
| A | GLN300 |
| A | GLU335 |
| A | ASP359 |
| A | SER391 |
| A | TYR437 |
| A | ASN524 |
| A | HIS525 |
| A | MN600 |
| A | ARG16 |
| A | TRP88 |
| A | PRO114 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 600 |
| Chain | Residue |
| B | GLU335 |
| B | ASP359 |
| B | HIS525 |
| B | FOC601 |
| B | HOH2216 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE FOC B 601 |
| Chain | Residue |
| B | ARG16 |
| B | TRP88 |
| B | GLN300 |
| B | GLU335 |
| B | ASP359 |
| B | SER391 |
| B | TYR437 |
| B | ASN524 |
| B | HIS525 |
| B | MN600 |
| B | HOH2224 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 1589 |
| Chain | Residue |
| B | ILE538 |
| B | ALA541 |
| B | SER542 |
| B | ILE546 |
| B | PRO547 |
| B | VAL548 |
| B | ARG560 |
| B | ASP576 |
| B | CYS580 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1589 |
| Chain | Residue |
| A | GLU197 |
| A | TYR198 |
| A | GLY467 |
| A | HOH2134 |
| A | HOH2269 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1590 |
| Chain | Residue |
| A | PRO99 |
| B | ARG171 |
| B | ASP172 |
| B | HIS587 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1590 |
| Chain | Residue |
| A | LEU119 |
| A | ASN519 |
| A | LYS562 |
| A | HOH2290 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1591 |
| Chain | Residue |
| A | THR209 |
| A | THR212 |
| A | TRP303 |
| A | PHE307 |
| B | THR209 |
| B | THR212 |
| B | TRP303 |
| B | PHE307 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1592 |
| Chain | Residue |
| B | ASP193 |
| B | PHE194 |
| B | GLU197 |
| B | TYR198 |
| B | GLY467 |
| B | HOH2132 |
| B | HOH2266 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1593 |
| Chain | Residue |
| B | LEU119 |
| B | GLY135 |
| B | ASN519 |
| B | LYS562 |
| B | HOH2294 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1591 |
| Chain | Residue |
| A | HIS551 |
| A | GLU555 |
| A | GLU570 |
| A | HOH2302 |
| A | HOH2323 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1592 |
| Chain | Residue |
| A | TYR476 |
| A | ARG504 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1594 |
| Chain | Residue |
| B | ARG159 |
| B | GLU556 |
| B | ASP557 |
| B | PHE559 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 1595 |
| Chain | Residue |
| B | ALA116 |
| B | VAL117 |
| B | ALA120 |
| B | VAL360 |
| B | MET518 |
| B | TRP521 |
| B | ALA523 |
| B | ASN524 |
| B | HOH2294 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 1596 |
| Chain | Residue |
| B | ARG504 |
| B | PRO554 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1597 |
| Chain | Residue |
| B | LEU43 |
| B | LYS44 |
| B | ASN352 |
| B | HOH2219 |
| B | THR42 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 1598 |
| Chain | Residue |
| B | GLU556 |
| B | ASP557 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1599 |
| Chain | Residue |
| A | ARG217 |
| B | ARG435 |
| B | ARG439 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1593 |
| Chain | Residue |
| A | ARG435 |
| A | ARG439 |
| B | ARG217 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01254","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01254","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
