4C08
Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CaCl2 at 1.34 Angstroms
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0006281 | biological_process | DNA repair |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008469 | molecular_function | histone arginine N-methyltransferase activity |
| A | 0010821 | biological_process | regulation of mitochondrion organization |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| A | 0032259 | biological_process | methylation |
| A | 0035241 | molecular_function | protein-arginine omega-N monomethyltransferase activity |
| A | 0035242 | molecular_function | protein-arginine omega-N asymmetric methyltransferase activity |
| A | 0036211 | biological_process | protein modification process |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0042393 | molecular_function | histone binding |
| A | 0044020 | molecular_function | histone H4R3 methyltransferase activity |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0070611 | molecular_function | histone H3R2 methyltransferase activity |
| A | 0070612 | molecular_function | histone H2AR3 methyltransferase activity |
| A | 0090398 | biological_process | cellular senescence |
| A | 1901796 | biological_process | regulation of signal transduction by p53 class mediator |
| A | 2000059 | biological_process | negative regulation of ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PE A 1378 |
| Chain | Residue |
| A | TRP81 |
| A | GLN105 |
| A | SER117 |
| A | ALA118 |
| A | GLU144 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1379 |
| Chain | Residue |
| A | HOH2126 |
| A | HOH2129 |
| A | GLU158 |
| A | MET160 |
| A | HOH2019 |
| A | HOH2125 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1380 |
| Chain | Residue |
| A | GLY275 |
| A | HOH2162 |
| A | HOH2228 |
| A | HOH2236 |
| A | HOH2241 |
| A | HOH2242 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1381 |
| Chain | Residue |
| A | ARG255 |
| A | HOH2223 |
| A | HOH2224 |
| A | HOH2225 |
| A | HOH2226 |
| A | HOH2229 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1382 |
| Chain | Residue |
| A | GLU167 |
| A | HOH2137 |
| A | HOH2141 |
| A | HOH2143 |
| A | HOH2144 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1383 |
| Chain | Residue |
| A | GLN242 |
| A | ASP243 |
| A | HOH2199 |
| A | HOH2200 |
| A | HOH2203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU158 | |
| A | GLU167 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS60 | |
| A | ARG69 | |
| A | GLY93 | |
| A | GLU115 | |
| A | GLU144 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Asymmetric dimethylarginine; by autocatalysis => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG38 |
