4C07
Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CaCl2 at 1.5 Angstroms
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0010468 | biological_process | regulation of gene expression |
| A | 0010821 | biological_process | regulation of mitochondrion organization |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| A | 0035241 | molecular_function | protein-arginine omega-N monomethyltransferase activity |
| A | 0035242 | molecular_function | protein-arginine omega-N asymmetric methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0042393 | molecular_function | histone binding |
| A | 0044020 | molecular_function | histone H4R3 methyltransferase activity |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0070611 | molecular_function | histone H3R2 methyltransferase activity |
| A | 0070612 | molecular_function | histone H2AR3 methyltransferase activity |
| A | 0090068 | biological_process | positive regulation of cell cycle process |
| A | 0090398 | biological_process | cellular senescence |
| A | 0140938 | molecular_function | histone H3 methyltransferase activity |
| A | 1901796 | biological_process | regulation of signal transduction by p53 class mediator |
| A | 2000059 | biological_process | negative regulation of ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1377 |
| Chain | Residue |
| A | GLU158 |
| A | MET160 |
| A | HOH2014 |
| A | HOH2084 |
| A | HOH2089 |
| A | HOH2090 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 1378 |
| Chain | Residue |
| A | GLU167 |
| A | HOH2097 |
| A | HOH2252 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 1379 |
| Chain | Residue |
| A | GLN242 |
| A | ASP243 |
| A | HOH2146 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1380 |
| Chain | Residue |
| A | GLY275 |
| A | HOH2167 |
| A | HOH2178 |
| A | HOH2254 |
| A | HOH2255 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1381 |
| Chain | Residue |
| A | ARG255 |
| A | HOH2162 |
| A | HOH2163 |
| A | HOH2164 |
| A | HOH2168 |
| A | HOH2256 |
| A | HOH2257 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 1382 |
| Chain | Residue |
| A | ASP339 |
| A | HOH2191 |
| A | HOH2258 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q96LA8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
