4C00

Crystal structure of TamA from E. coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009279	cellular_component	cell outer membrane
A	0009306	biological_process	protein secretion
A	0015031	biological_process	protein transport
A	0019867	cellular_component	outer membrane
A	0089705	biological_process	protein localization to outer membrane
A	0097347	cellular_component	TAM protein secretion complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MC3 A 601

Chain	Residue
A	VAL282
A	TYR506
A	TYR508
A	MC3608
A	MC3611
A	HOH2221
A	ALA284
A	ILE304
A	SER305
A	ALA306
A	GLN309
A	LEU311
A	ARG442
A	HIS443

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MC3 A 602

Chain	Residue
A	ASN292
A	SER293
A	TYR294
A	TYR315
A	GLN331
A	GLY332
A	MC3611
A	MC3613

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MC3 A 603

Chain	Residue
A	ASN433
A	THR447
A	ARG448
A	GLY449
A	ILE500
A	SER503
A	SER522
A	PHE534
A	THR536
A	MC3616

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MC3 A 604

Chain	Residue
A	PHE334
A	ARG336

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MC3 A 605

Chain	Residue
A	TRP514
A	TRP544

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MC3 A 606

Chain	Residue
A	THR270
A	VAL272
A	LEU573
A	MC3608

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MC3 A 607

Chain	Residue
A	SER359
A	TRP361
A	ARG363

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MC3 A 608

Chain	Residue
A	TYR440
A	HIS443
A	TYR506
A	MC3601
A	MC3606

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MC3 A 609

Chain	Residue
A	MC3612
A	MC3615

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MC3 A 610

Chain	Residue
A	MET384
A	TRP420
A	GLY421
A	MC3614

---

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MC3 A 611

Chain	Residue
A	GLU265
A	TRP286
A	LYS288
A	TRP290
A	MET291
A	LEU298
A	GLY516
A	LEU567
A	MC3601
A	MC3602
A	HOH2070
A	HOH2220

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MC3 A 612

Chain	Residue
A	GLU325
A	TRP355
A	LEU357
A	ARG363
A	VAL390
A	MC3609

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MC3 A 613

Chain	Residue
A	TYR294
A	HIS296
A	TRP453
A	LYS498
A	SER527
A	ASP528
A	ILE529
A	ARG530
A	MC3602

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MC3 A 614

Chain	Residue
A	ARG396
A	TRP405
A	ARG437
A	MC3610

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MC3 A 615

Chain	Residue
A	TYR328
A	ARG353
A	ILE529
A	ARG530
A	SER532
A	MC3609
A	CL802

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MC3 A 616

Chain	Residue
A	ARG394
A	GLN409
A	MC3603

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 701

Chain	Residue
A	HOH2101
A	ARG228
A	LEU324
A	LEU357
A	SER358

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 702

Chain	Residue
A	SER297
A	THR299
A	SER314

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 801

Chain	Residue
A	ASP460
A	ARG467
A	TYR488

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 802

Chain	Residue
A	LEU319
A	LEU320
A	ARG530
A	MC3615
A	HOH2040

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 803

Chain	Residue
A	ARG368
A	HOH2128

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	13
Details	LIPOCALIN Lipocalin signature. EYQy.NVTGKWWGA

Chain	Residue	Details
A	GLU505-ALA517

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	142
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"24056943","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	102
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24056943","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	33
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"24056943","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"24056943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25341963","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	76
Details	Domain: {"description":"POTRA","evidences":[{"source":"PROSITE-ProRule","id":"PRU01115","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	63
Details	Region: {"description":"POTRA2","evidences":[{"source":"PubMed","id":"26243377","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	79
Details	Region: {"description":"POTRA3","evidences":[{"source":"PubMed","id":"26243377","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	333
Details	Region: {"description":"Sufficient for outer membrane targeting"}

Chain

Residue

Details

---