Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4BZI

The structure of the COPII coat assembled on membranes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0003400	biological_process	regulation of COPII vesicle coating
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0008270	molecular_function	zinc ion binding
A	0012507	cellular_component	ER to Golgi transport vesicle membrane
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0016236	biological_process	macroautophagy
A	0030127	cellular_component	COPII vesicle coat
A	0031410	cellular_component	cytoplasmic vesicle
A	0046872	molecular_function	metal ion binding
A	0061709	biological_process	reticulophagy
A	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
A	0070971	cellular_component	endoplasmic reticulum exit site
A	0090110	biological_process	COPII-coated vesicle cargo loading
A	0090114	biological_process	COPII-coated vesicle budding
A	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
B	0000139	cellular_component	Golgi membrane
B	0000266	biological_process	mitochondrial fission
B	0003400	biological_process	regulation of COPII vesicle coating
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0006886	biological_process	intracellular protein transport
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0006998	biological_process	nuclear envelope organization
B	0007006	biological_process	mitochondrial membrane organization
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016050	biological_process	vesicle organization
B	0016192	biological_process	vesicle-mediated transport
B	0016787	molecular_function	hydrolase activity
B	0030127	cellular_component	COPII vesicle coat
B	0031410	cellular_component	cytoplasmic vesicle
B	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
B	0061024	biological_process	membrane organization
B	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
B	0070971	cellular_component	endoplasmic reticulum exit site
B	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
D	0000139	cellular_component	Golgi membrane
D	0003400	biological_process	regulation of COPII vesicle coating
D	0005096	molecular_function	GTPase activator activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0006886	biological_process	intracellular protein transport
D	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
D	0008270	molecular_function	zinc ion binding
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0016192	biological_process	vesicle-mediated transport
D	0016236	biological_process	macroautophagy
D	0030127	cellular_component	COPII vesicle coat
D	0031410	cellular_component	cytoplasmic vesicle
D	0046872	molecular_function	metal ion binding
D	0061709	biological_process	reticulophagy
D	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
D	0070971	cellular_component	endoplasmic reticulum exit site
D	0090110	biological_process	COPII-coated vesicle cargo loading
D	0090114	biological_process	COPII-coated vesicle budding
D	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
E	0000139	cellular_component	Golgi membrane
E	0000149	molecular_function	SNARE binding
E	0000329	cellular_component	fungal-type vacuole membrane
E	0005048	molecular_function	signal sequence binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0006886	biological_process	intracellular protein transport
E	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
E	0008270	molecular_function	zinc ion binding
E	0012507	cellular_component	ER to Golgi transport vesicle membrane
E	0015031	biological_process	protein transport
E	0016020	cellular_component	membrane
E	0016192	biological_process	vesicle-mediated transport
E	0016236	biological_process	macroautophagy
E	0030127	cellular_component	COPII vesicle coat
E	0031410	cellular_component	cytoplasmic vesicle
E	0046872	molecular_function	metal ion binding
E	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
E	0070971	cellular_component	endoplasmic reticulum exit site
E	0090110	biological_process	COPII-coated vesicle cargo loading
E	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
F	0000139	cellular_component	Golgi membrane
F	0000149	molecular_function	SNARE binding
F	0000329	cellular_component	fungal-type vacuole membrane
F	0005048	molecular_function	signal sequence binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0006886	biological_process	intracellular protein transport
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0008270	molecular_function	zinc ion binding
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0015031	biological_process	protein transport
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
F	0016236	biological_process	macroautophagy
F	0030127	cellular_component	COPII vesicle coat
F	0031410	cellular_component	cytoplasmic vesicle
F	0046872	molecular_function	metal ion binding
F	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
F	0070971	cellular_component	endoplasmic reticulum exit site
F	0090110	biological_process	COPII-coated vesicle cargo loading
F	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
G	0000139	cellular_component	Golgi membrane
G	0003400	biological_process	regulation of COPII vesicle coating
G	0005096	molecular_function	GTPase activator activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005794	cellular_component	Golgi apparatus
G	0006886	biological_process	intracellular protein transport
G	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
G	0008270	molecular_function	zinc ion binding
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0016192	biological_process	vesicle-mediated transport
G	0016236	biological_process	macroautophagy
G	0030127	cellular_component	COPII vesicle coat
G	0031410	cellular_component	cytoplasmic vesicle
G	0046872	molecular_function	metal ion binding
G	0061709	biological_process	reticulophagy
G	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
G	0070971	cellular_component	endoplasmic reticulum exit site
G	0090110	biological_process	COPII-coated vesicle cargo loading
G	0090114	biological_process	COPII-coated vesicle budding
G	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
J	0000139	cellular_component	Golgi membrane
J	0000266	biological_process	mitochondrial fission
J	0003400	biological_process	regulation of COPII vesicle coating
J	0003924	molecular_function	GTPase activity
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005739	cellular_component	mitochondrion
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0005794	cellular_component	Golgi apparatus
J	0006886	biological_process	intracellular protein transport
J	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
J	0006998	biological_process	nuclear envelope organization
J	0007006	biological_process	mitochondrial membrane organization
J	0012507	cellular_component	ER to Golgi transport vesicle membrane
J	0015031	biological_process	protein transport
J	0016020	cellular_component	membrane
J	0016050	biological_process	vesicle organization
J	0016192	biological_process	vesicle-mediated transport
J	0016787	molecular_function	hydrolase activity
J	0030127	cellular_component	COPII vesicle coat
J	0031410	cellular_component	cytoplasmic vesicle
J	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
J	0061024	biological_process	membrane organization
J	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
J	0070971	cellular_component	endoplasmic reticulum exit site
J	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
K	0000139	cellular_component	Golgi membrane
K	0000266	biological_process	mitochondrial fission
K	0003400	biological_process	regulation of COPII vesicle coating
K	0003924	molecular_function	GTPase activity
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005739	cellular_component	mitochondrion
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005794	cellular_component	Golgi apparatus
K	0006886	biological_process	intracellular protein transport
K	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
K	0006998	biological_process	nuclear envelope organization
K	0007006	biological_process	mitochondrial membrane organization
K	0012507	cellular_component	ER to Golgi transport vesicle membrane
K	0015031	biological_process	protein transport
K	0016020	cellular_component	membrane
K	0016050	biological_process	vesicle organization
K	0016192	biological_process	vesicle-mediated transport
K	0016787	molecular_function	hydrolase activity
K	0030127	cellular_component	COPII vesicle coat
K	0031410	cellular_component	cytoplasmic vesicle
K	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
K	0061024	biological_process	membrane organization
K	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
K	0070971	cellular_component	endoplasmic reticulum exit site
K	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
L	0000139	cellular_component	Golgi membrane
L	0000149	molecular_function	SNARE binding
L	0000329	cellular_component	fungal-type vacuole membrane
L	0005048	molecular_function	signal sequence binding
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0005794	cellular_component	Golgi apparatus
L	0006886	biological_process	intracellular protein transport
L	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
L	0008270	molecular_function	zinc ion binding
L	0012507	cellular_component	ER to Golgi transport vesicle membrane
L	0015031	biological_process	protein transport
L	0016020	cellular_component	membrane
L	0016192	biological_process	vesicle-mediated transport
L	0016236	biological_process	macroautophagy
L	0030127	cellular_component	COPII vesicle coat
L	0031410	cellular_component	cytoplasmic vesicle
L	0046872	molecular_function	metal ion binding
L	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
L	0070971	cellular_component	endoplasmic reticulum exit site
L	0090110	biological_process	COPII-coated vesicle cargo loading
L	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
M	0000139	cellular_component	Golgi membrane
M	0000149	molecular_function	SNARE binding
M	0000329	cellular_component	fungal-type vacuole membrane
M	0005048	molecular_function	signal sequence binding
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005783	cellular_component	endoplasmic reticulum
M	0005789	cellular_component	endoplasmic reticulum membrane
M	0005794	cellular_component	Golgi apparatus
M	0006886	biological_process	intracellular protein transport
M	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
M	0008270	molecular_function	zinc ion binding
M	0012507	cellular_component	ER to Golgi transport vesicle membrane
M	0015031	biological_process	protein transport
M	0016020	cellular_component	membrane
M	0016192	biological_process	vesicle-mediated transport
M	0016236	biological_process	macroautophagy
M	0030127	cellular_component	COPII vesicle coat
M	0031410	cellular_component	cytoplasmic vesicle
M	0046872	molecular_function	metal ion binding
M	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
M	0070971	cellular_component	endoplasmic reticulum exit site
M	0090110	biological_process	COPII-coated vesicle cargo loading
M	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
N	0000139	cellular_component	Golgi membrane
N	0000149	molecular_function	SNARE binding
N	0000329	cellular_component	fungal-type vacuole membrane
N	0005048	molecular_function	signal sequence binding
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005783	cellular_component	endoplasmic reticulum
N	0005789	cellular_component	endoplasmic reticulum membrane
N	0005794	cellular_component	Golgi apparatus
N	0006886	biological_process	intracellular protein transport
N	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
N	0008270	molecular_function	zinc ion binding
N	0012507	cellular_component	ER to Golgi transport vesicle membrane
N	0015031	biological_process	protein transport
N	0016020	cellular_component	membrane
N	0016192	biological_process	vesicle-mediated transport
N	0016236	biological_process	macroautophagy
N	0030127	cellular_component	COPII vesicle coat
N	0031410	cellular_component	cytoplasmic vesicle
N	0046872	molecular_function	metal ion binding
N	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
N	0070971	cellular_component	endoplasmic reticulum exit site
N	0090110	biological_process	COPII-coated vesicle cargo loading
N	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
O	0000139	cellular_component	Golgi membrane
O	0000149	molecular_function	SNARE binding
O	0000329	cellular_component	fungal-type vacuole membrane
O	0005048	molecular_function	signal sequence binding
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005783	cellular_component	endoplasmic reticulum
O	0005789	cellular_component	endoplasmic reticulum membrane
O	0005794	cellular_component	Golgi apparatus
O	0006886	biological_process	intracellular protein transport
O	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
O	0008270	molecular_function	zinc ion binding
O	0012507	cellular_component	ER to Golgi transport vesicle membrane
O	0015031	biological_process	protein transport
O	0016020	cellular_component	membrane
O	0016192	biological_process	vesicle-mediated transport
O	0016236	biological_process	macroautophagy
O	0030127	cellular_component	COPII vesicle coat
O	0031410	cellular_component	cytoplasmic vesicle
O	0046872	molecular_function	metal ion binding
O	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
O	0070971	cellular_component	endoplasmic reticulum exit site
O	0090110	biological_process	COPII-coated vesicle cargo loading
O	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1769

Chain	Residue
A	CYS56
A	CYS61
A	CYS80
A	CYS83

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP B 1190

Chain	Residue
B	LYS36
B	THR37
B	THR38
B	PRO53
B	THR54
B	GLY76
B	ASN132
B	LYS133
B	ASP135
B	SER172
B	VAL173
B	VAL174
B	MG1191
A	ARG722
B	ASP32
B	ASN33
B	ALA34
B	GLY35

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 1191

Chain	Residue
B	THR37
B	THR54
B	GNP1190

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1769

Chain	Residue
D	CYS56
D	CYS61
D	CYS80
D	CYS83

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1927

Chain	Residue
E	CYS231
E	CYS234
E	CYS253
E	CYS256

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 1769

Chain	Residue
G	CYS56
G	CYS61
G	CYS80
G	CYS83

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP J 1190

Chain	Residue
D	ARG722
J	ASP32
J	ASN33
J	ALA34
J	GLY35
J	LYS36
J	THR37
J	THR38
J	PRO53
J	THR54
J	GLY76
J	ASN132
J	LYS133
J	ASP135
J	SER172
J	VAL173
J	VAL174
J	MG1191

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG J 1191

Chain	Residue
J	THR37
J	THR54
J	GNP1190

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP K 1190

Chain	Residue
G	ARG722
K	ASP32
K	ASN33
K	ALA34
K	GLY35
K	LYS36
K	THR37
K	THR38
K	PRO53
K	THR54
K	GLY76
K	ASN132
K	LYS133
K	ASP135
K	SER172
K	VAL173
K	VAL174
K	MG1191

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG K 1191

Chain	Residue
K	THR37
K	THR54
K	GNP1190

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 1927

Chain	Residue
L	CYS231
L	CYS234
L	CYS253
L	CYS256

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 1927

Chain	Residue
M	CYS231
M	CYS234
M	CYS253
M	CYS256

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:12239560, ECO:0000269\|PubMed:12941276

Chain	Residue	Details
F	CYS231
O	CYS425
O	CYS444
O	CYS447
F	CYS234
F	CYS253
F	CYS256
N	CYS422
N	CYS425
N	CYS444
N	CYS447
O	CYS422

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17330950

Chain	Residue	Details
F	SER178
N	SER369
O	SER369

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
B	SER157
J	SER157
K	SER157

site_id	SWS_FT_FI4
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744\|PubMed:22106047

Chain	Residue	Details
B	LYS133
J	LYS133
K	LYS133

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)