4BZ8
Crystal structure of Schistosoma mansoni HDAC8 complexed with J1038
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
A | 0004407 | molecular_function | histone deacetylase activity |
A | 0005634 | cellular_component | nucleus |
A | 0006338 | biological_process | chromatin remodeling |
A | 0046872 | molecular_function | metal ion binding |
B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
B | 0004407 | molecular_function | histone deacetylase activity |
B | 0005634 | cellular_component | nucleus |
B | 0006338 | biological_process | chromatin remodeling |
B | 0046872 | molecular_function | metal ion binding |
C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
C | 0004407 | molecular_function | histone deacetylase activity |
C | 0005634 | cellular_component | nucleus |
C | 0006338 | biological_process | chromatin remodeling |
C | 0046872 | molecular_function | metal ion binding |
D | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
D | 0004407 | molecular_function | histone deacetylase activity |
D | 0005634 | cellular_component | nucleus |
D | 0006338 | biological_process | chromatin remodeling |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 500 |
Chain | Residue |
A | ASP186 |
A | HIS188 |
A | ASP285 |
A | J38700 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K A 600 |
Chain | Residue |
A | PHE197 |
A | SER200 |
A | VAL203 |
A | SER243 |
A | HOH2082 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K A 601 |
Chain | Residue |
A | ASP184 |
A | ASP186 |
A | HIS188 |
A | SER207 |
A | VAL208 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE J38 A 700 |
Chain | Residue |
A | ASP100 |
A | HIS141 |
A | HIS142 |
A | GLY150 |
A | PHE151 |
A | ASP186 |
A | HIS188 |
A | PHE216 |
A | ASP285 |
A | HIS292 |
A | TYR341 |
A | ZN500 |
B | ASP50 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 500 |
Chain | Residue |
B | ASP186 |
B | HIS188 |
B | ASP285 |
B | J38700 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 600 |
Chain | Residue |
B | PHE197 |
B | SER200 |
B | VAL203 |
B | SER243 |
B | HOH2060 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 601 |
Chain | Residue |
B | ASP184 |
B | ASP186 |
B | HIS188 |
B | SER207 |
B | VAL208 |
site_id | AC8 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE J38 B 700 |
Chain | Residue |
A | ASP50 |
B | ASP100 |
B | HIS141 |
B | HIS142 |
B | GLY150 |
B | PHE151 |
B | ASP186 |
B | HIS188 |
B | PHE216 |
B | ASP285 |
B | HIS292 |
B | TYR341 |
B | ZN500 |
B | HOH2037 |
B | HOH2046 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 500 |
Chain | Residue |
C | ASP186 |
C | HIS188 |
C | ASP285 |
C | J38700 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K C 600 |
Chain | Residue |
C | ASP184 |
C | ASP186 |
C | HIS188 |
C | SER207 |
C | VAL208 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K C 601 |
Chain | Residue |
C | PHE197 |
C | SER200 |
C | VAL203 |
C | SER243 |
C | HOH2080 |
site_id | BC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE J38 C 700 |
Chain | Residue |
C | HIS141 |
C | HIS142 |
C | GLY150 |
C | PHE151 |
C | ASP186 |
C | HIS188 |
C | PHE216 |
C | ASP285 |
C | HIS292 |
C | TYR341 |
C | ZN500 |
D | ASP50 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 500 |
Chain | Residue |
D | ASP186 |
D | HIS188 |
D | ASP285 |
D | J38700 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K D 600 |
Chain | Residue |
D | PHE197 |
D | SER200 |
D | VAL203 |
D | SER243 |
D | HOH2073 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K D 601 |
Chain | Residue |
D | ASP184 |
D | ASP186 |
D | HIS188 |
D | SER207 |
D | VAL208 |
site_id | BC7 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE J38 D 700 |
Chain | Residue |
D | HIS141 |
D | HIS142 |
D | GLY150 |
D | PHE151 |
D | ASP186 |
D | HIS188 |
D | PHE216 |
D | ASP285 |
D | HIS292 |
D | TYR341 |
D | ZN500 |
C | ASP50 |
C | HOH2035 |
D | ASP100 |