4BY4
Crystal structure of Drosophila Frq2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0007269 | biological_process | neurotransmitter secretion |
| A | 0007528 | biological_process | neuromuscular junction development |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046928 | biological_process | regulation of neurotransmitter secretion |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0007269 | biological_process | neurotransmitter secretion |
| B | 0007528 | biological_process | neuromuscular junction development |
| B | 0008021 | cellular_component | synaptic vesicle |
| B | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| B | 0016192 | biological_process | vesicle-mediated transport |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046928 | biological_process | regulation of neurotransmitter secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1184 |
| Chain | Residue |
| A | ASP73 |
| A | ASN75 |
| A | ASP77 |
| A | ALA79 |
| A | GLU84 |
| A | HOH2040 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1185 |
| Chain | Residue |
| A | TYR115 |
| A | GLU120 |
| A | HOH2062 |
| A | ASP109 |
| A | ASP111 |
| A | ASP113 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1186 |
| Chain | Residue |
| A | ASP156 |
| A | ASN158 |
| A | ASP160 |
| A | ARG162 |
| A | GLU167 |
| A | HOH2071 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1184 |
| Chain | Residue |
| B | ASP73 |
| B | ASN75 |
| B | ASP77 |
| B | ALA79 |
| B | GLU84 |
| B | HOH2021 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1185 |
| Chain | Residue |
| B | ASP109 |
| B | ASP111 |
| B | ASP113 |
| B | TYR115 |
| B | GLU120 |
| B | HOH2036 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1186 |
| Chain | Residue |
| B | ASP156 |
| B | ASN158 |
| B | ASP160 |
| B | ARG162 |
| B | GLU167 |
| B | HOH2037 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1187 |
| Chain | Residue |
| A | THR17 |
| A | THR20 |
| A | HOH2008 |
| A | HOH2009 |
| A | HOH2010 |
| B | ASP11 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DENNDGAIEfeEF |
| Chain | Residue | Details |
| A | ASP73-PHE85 | |
| A | ASP109-MET121 | |
| A | ASP156-PHE168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25074811, ECO:0000269|PubMed:28119500, ECO:0000269|PubMed:29966094, ECO:0007744|PDB:4BY4, ECO:0007744|PDB:4BY5, ECO:0007744|PDB:5AAN, ECO:0007744|PDB:5FYX, ECO:0007744|PDB:5G08, ECO:0007744|PDB:6EPA |
| Chain | Residue | Details |
| A | ASP73 | |
| A | GLU120 | |
| A | ASP156 | |
| A | ASN158 | |
| A | ASP160 | |
| A | ARG162 | |
| A | GLU167 | |
| B | ASP73 | |
| B | ASN75 | |
| B | ASP77 | |
| B | ALA79 | |
| A | ASN75 | |
| B | GLU84 | |
| B | ASP109 | |
| B | ASP111 | |
| B | ASP113 | |
| B | TYR115 | |
| B | GLU120 | |
| B | ASP156 | |
| B | ASN158 | |
| B | ASP160 | |
| B | ARG162 | |
| A | ASP77 | |
| B | GLU167 | |
| A | ALA79 | |
| A | GLU84 | |
| A | ASP109 | |
| A | ASP111 | |
| A | ASP113 | |
| A | TYR115 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | LIPID: N-myristoyl glycine => ECO:0000250|UniProtKB:P62168 |
| Chain | Residue | Details |
| A | GLY2 | |
| B | GLY2 |
