4BWR

Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold

Replaces:  2XM6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009986	cellular_component	cell surface
A	0019862	molecular_function	IgA binding
A	0046872	molecular_function	metal ion binding
A	0050777	biological_process	negative regulation of immune response
A	1902564	biological_process	negative regulation of neutrophil activation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1468

Chain	Residue
A	HIS99
A	GLU136
A	ASP138
A	HOH2026
A	HOH2039
A	HOH2040

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1469

Chain	Residue
A	ARG123

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1470

Chain	Residue
A	TYR272

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1471

Chain	Residue
A	LYS250
A	EDO1486
A	HOH3030
A	HOH3278
A	ALA249

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1472

Chain	Residue
A	ASP279
A	LYS287
A	HOH2085
A	HOH3219
A	HOH3236

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1473

Chain	Residue
A	ASP143
A	TYR144
A	HOH3078
A	HOH3079

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1474

Chain	Residue
A	LYS254
A	GLU257

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1475

Chain	Residue
A	LEU256
A	GLY284
A	ALA286
A	HOH2082
A	HOH3120

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1476

Chain	Residue
A	GLN459
A	SER460

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1477

Chain	Residue
A	GLU384
A	TYR387
A	TYR388
A	ASN418
A	ILE421

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1478

Chain	Residue
A	PHE115
A	SER129
A	ASP132

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1479

Chain	Residue
A	ARG188
A	LYS189
A	THR192
A	HOH3095
A	HOH3126

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1480

Chain	Residue
A	GLN381
A	GLU384
A	LEU390
A	EDO1498
A	HOH2116
A	HOH3218

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1481

Chain	Residue
A	SER268
A	GLN302
A	ASP304
A	HOH2073
A	HOH3061
A	HOH3141

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1482

Chain	Residue
A	GLN127
A	LYS153
A	GLN157
A	EDO1483
A	HOH3132

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1483

Chain	Residue
A	ALA119
A	GLU120
A	GLN127
A	LYS153
A	EDO1482
A	EDO1491

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1484

Chain	Residue
A	LYS254
A	GLU257
A	TRP258
A	LYS261
A	HOH3332

---

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1485

Chain	Residue
A	TYR240
A	GLU243
A	GLN244
A	TYR273
A	HIS276
A	HOH2066
A	HOH3227
A	HOH3229

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1486

Chain	Residue
A	GLY248
A	ALA249
A	EDO1471

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1487

Chain	Residue
A	ASP107
A	LYS108
A	ALA109
A	GLN218
A	HOH2053
A	HOH3209

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1488

Chain	Residue
A	GLU329
A	TRP330
A	LYS333

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1489

Chain	Residue
A	LYS250
A	PRO252
A	ALA282
A	GLU283
A	HOH2064
A	HOH3027

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1490

Chain	Residue
A	LEU413
A	PHE414
A	ASN412

---

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1491

Chain	Residue
A	MSE146
A	GLU149
A	TRP150
A	LYS153
A	EDO1483

---

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1492

Chain	Residue
A	ARG452
A	LYS455
A	HOH2127

---

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1493

Chain	Residue
A	ASN267
A	HOH2091
A	HOH3308

---

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1494

Chain	Residue
A	TYR207
A	PHE208
A	TYR273

---

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1495

Chain	Residue
A	ARG178
A	ASN179
A	ASP180
A	HOH3139

---

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1496

Chain	Residue
A	ASP71
A	GLN74

---

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1497

Chain	Residue
A	ARG220
A	SER224
A	HOH3058
A	HOH3439

---

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1498

Chain	Residue
A	EDO1480
A	HOH2104

---

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1499

Chain	Residue
A	ASP395

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Repeat: {"description":"Sel1-like 7","evidences":[{"source":"PubMed","id":"24099525","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Repeat: {"description":"Sel1-like 8","evidences":[{"source":"PubMed","id":"24099525","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	33
Details	Repeat: {"description":"Sel1-like 9","evidences":[{"source":"PubMed","id":"24099525","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	31
Details	Repeat: {"description":"Sel1-like 11","evidences":[{"source":"PubMed","id":"24099525","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24099525","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---