Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4BW3

The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand

Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO A 1169
ChainResidue
AEDO1171
AHOH2085

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 1170
ChainResidue
AGLN64
ALYS155
AGLN159

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1171
ChainResidue
AEDO1169
AHOH2085
APRO86
AGLY108
ATHR109
ALYS112

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 9BM A 1172
ChainResidue
ASER51
ALYS57
ATRP81
APRO82
APHE83
ALEU92
AASN116
AASN140
AILE146
AHOH2081
AHOH2110
AHOH2188
AHOH2189

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

PDB statisticsPDBj update infoContact PDBjnumon