4BUO

High Resolution Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016492	molecular_function	G protein-coupled neurotensin receptor activity
B	0004930	molecular_function	G protein-coupled receptor activity
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0016492	molecular_function	G protein-coupled neurotensin receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GLY A 1385

Chain	Residue
A	PHE206

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GLY A 1386

Chain	Residue
A	ASP103
A	TYR104

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GLY A 1387

Chain	Residue
A	GLU166
A	MET181
B	PHE243

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GLY A 1389

Chain	Residue
A	LEU322
A	VAL326

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GLY A 1390

Chain	Residue
A	ALA140

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GLY A 1391

Chain	Residue
A	PHE206

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GLY B 1387

Chain	Residue
B	TRP194

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GLY B 1388

Chain	Residue
B	GLN99
B	ARG305
B	SER373
B	ASN375

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GLY B 1389

Chain	Residue
A	LEU247
A	PHE248
B	LEU180
B	MET181
B	PHE189

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Cleavage; by MME => ECO:0000250|UniProtKB:P30990

Chain	Residue	Details
C	PRO10
D	PRO10

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by ACE and MME => ECO:0000250|UniProtKB:P30990

Chain	Residue	Details
C	TYR11
D	TYR11
A	ALA261-VAL326
B	ALA90-ASP103
B	GLU166-ARG185
B	ALA261-VAL326

---

site_id	SWS_FT_FI3
Number of Residues	38
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR104-VAL123
B	TYR104-VAL123

---

site_id	SWS_FT_FI4
Number of Residues	128
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:24453215

Chain	Residue	Details
A	GLU124-ARG143
A	THR207-LYS235
A	PHE331-HIS348
B	GLU124-ARG143
B	THR207-LYS235
B	PHE331-HIS348

---

site_id	SWS_FT_FI5
Number of Residues	42
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	GLY144-VAL165
B	GLY144-VAL165

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	THR186-PHE206
B	THR186-PHE206

---

site_id	SWS_FT_FI7
Number of Residues	48
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	VAL236-ILE260
B	VAL236-ILE260

---

site_id	SWS_FT_FI8
Number of Residues	42
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	VAL309-MET330
B	VAL309-MET330

---

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	TYR349-TYR369
B	TYR349-TYR369

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P30989

Chain	Residue	Details
A	CYS386
A	CYS388
B	CYS386
B	CYS388

---