4BUJ
Crystal structure of the S. cerevisiae Ski2-3-8 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006401 | biological_process | RNA catabolic process |
| B | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| B | 0003674 | molecular_function | molecular_function |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006402 | biological_process | mRNA catabolic process |
| B | 0051607 | biological_process | defense response to virus |
| B | 0055087 | cellular_component | Ski complex |
| B | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| B | 0070481 | biological_process | nuclear-transcribed mRNA catabolic process, non-stop decay |
| C | 0000228 | cellular_component | nuclear chromosome |
| C | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| C | 0003674 | molecular_function | molecular_function |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005694 | cellular_component | chromosome |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006402 | biological_process | mRNA catabolic process |
| C | 0007131 | biological_process | reciprocal meiotic recombination |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0051321 | biological_process | meiotic cell cycle |
| C | 0051607 | biological_process | defense response to virus |
| C | 0055087 | cellular_component | Ski complex |
| C | 0065003 | biological_process | protein-containing complex assembly |
| C | 0065004 | biological_process | protein-DNA complex assembly |
| C | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| C | 0070481 | biological_process | nuclear-transcribed mRNA catabolic process, non-stop decay |
| D | 0000228 | cellular_component | nuclear chromosome |
| D | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| D | 0003674 | molecular_function | molecular_function |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005694 | cellular_component | chromosome |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006402 | biological_process | mRNA catabolic process |
| D | 0007131 | biological_process | reciprocal meiotic recombination |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0051321 | biological_process | meiotic cell cycle |
| D | 0051607 | biological_process | defense response to virus |
| D | 0055087 | cellular_component | Ski complex |
| D | 0065003 | biological_process | protein-containing complex assembly |
| D | 0065004 | biological_process | protein-DNA complex assembly |
| D | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| D | 0070481 | biological_process | nuclear-transcribed mRNA catabolic process, non-stop decay |
| E | 0003676 | molecular_function | nucleic acid binding |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003724 | molecular_function | RNA helicase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006401 | biological_process | RNA catabolic process |
| F | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| F | 0003674 | molecular_function | molecular_function |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006401 | biological_process | RNA catabolic process |
| F | 0006402 | biological_process | mRNA catabolic process |
| F | 0051607 | biological_process | defense response to virus |
| F | 0055087 | cellular_component | Ski complex |
| F | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| F | 0070481 | biological_process | nuclear-transcribed mRNA catabolic process, non-stop decay |
| G | 0000228 | cellular_component | nuclear chromosome |
| G | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| G | 0003674 | molecular_function | molecular_function |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005694 | cellular_component | chromosome |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006402 | biological_process | mRNA catabolic process |
| G | 0007131 | biological_process | reciprocal meiotic recombination |
| G | 0032991 | cellular_component | protein-containing complex |
| G | 0051321 | biological_process | meiotic cell cycle |
| G | 0051607 | biological_process | defense response to virus |
| G | 0055087 | cellular_component | Ski complex |
| G | 0065003 | biological_process | protein-containing complex assembly |
| G | 0065004 | biological_process | protein-DNA complex assembly |
| G | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| G | 0070481 | biological_process | nuclear-transcribed mRNA catabolic process, non-stop decay |
| H | 0000228 | cellular_component | nuclear chromosome |
| H | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| H | 0003674 | molecular_function | molecular_function |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005694 | cellular_component | chromosome |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006402 | biological_process | mRNA catabolic process |
| H | 0007131 | biological_process | reciprocal meiotic recombination |
| H | 0032991 | cellular_component | protein-containing complex |
| H | 0051321 | biological_process | meiotic cell cycle |
| H | 0051607 | biological_process | defense response to virus |
| H | 0055087 | cellular_component | Ski complex |
| H | 0065003 | biological_process | protein-containing complex assembly |
| H | 0065004 | biological_process | protein-DNA complex assembly |
| H | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| H | 0070481 | biological_process | nuclear-transcribed mRNA catabolic process, non-stop decay |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2001 |
| Chain | Residue |
| A | THR353 |
| A | SER354 |
| A | ALA355 |
| A | GLY356 |
| A | LYS357 |
| A | THR358 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2002 |
| Chain | Residue |
| A | SER635 |
| A | LYS636 |
| A | LYS637 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2003 |
| Chain | Residue |
| A | GLY697 |
| A | THR722 |
| A | THR724 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2004 |
| Chain | Residue |
| A | ARG1240 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2001 |
| Chain | Residue |
| B | ARG1376 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1001 |
| Chain | Residue |
| C | LYS240 |
| C | SER298 |
| C | LYS361 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1002 |
| Chain | Residue |
| B | PHE1416 |
| C | TRP125 |
| C | THR190 |
| C | ARG237 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1003 |
| Chain | Residue |
| C | LEU94 |
| C | LYS111 |
| C | LYS120 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1004 |
| Chain | Residue |
| A | ARG1270 |
| C | HIS279 |
| C | SER291 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1001 |
| Chain | Residue |
| D | LYS128 |
| D | LYS240 |
| D | SER298 |
| D | LYS361 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1002 |
| Chain | Residue |
| B | TYR1365 |
| D | TRP125 |
| D | THR190 |
| D | ARG237 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2001 |
| Chain | Residue |
| E | SER354 |
| E | ALA355 |
| E | GLY356 |
| E | LYS357 |
| E | THR358 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2002 |
| Chain | Residue |
| E | SER635 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2003 |
| Chain | Residue |
| E | GLY697 |
| E | THR722 |
| E | THR724 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 G 1001 |
| Chain | Residue |
| G | LYS240 |
| G | LYS361 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 G 1002 |
| Chain | Residue |
| F | PHE1416 |
| F | LEU1417 |
| G | TRP125 |
| G | THR190 |
| G | ARG237 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 G 1003 |
| Chain | Residue |
| G | LYS111 |
| G | LYS120 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 G 1004 |
| Chain | Residue |
| G | HIS279 |
| G | SER291 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 H 1001 |
| Chain | Residue |
| H | LYS128 |
| H | LYS240 |
| H | SER298 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 H 1002 |
| Chain | Residue |
| H | ARG270 |
| H | GLY272 |
| H | SER273 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. TVSCsgDgYLKVWDN |
| Chain | Residue | Details |
| C | THR29-ASN43 | |
| C | LEU306-VAL320 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 136 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Region: {"description":"RNA-binding RGG-box","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DEVH box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | Compositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"TPR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"TPR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"TPR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 62 |
| Details | Repeat: {"description":"TPR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 136 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 93 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 88 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 104 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
