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4BUI

Crystal structure of human tankyrase 2 in complex with methyl 4-(4- oxo-3,4-dihydroquinazolin-2-yl)benzoate

Functional Information from GO Data
ChainGOidnamespacecontents
A0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
C0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 2162
ChainResidue
ACYS1081
AHIS1084
ACYS1089
ACYS1092

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 2162
ChainResidue
CCYS1081
CHIS1084
CCYS1089
CCYS1092

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 2163
ChainResidue
AHIS979
AARG980
ALYS1067
AGLN1070
AHOH3042
AHOH3141
AHOH3205
AARG977

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 C 2163
ChainResidue
CARG977
CHIS979
CARG980
CLYS1067
CGLN1070
CHOH3038

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 C 2164
ChainResidue
CASN990
CARG991
CPRO1160
CGLU1161
CHOH3052

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 2164
ChainResidue
AASN990
AARG991
APRO1160
AGLU1161
AHOH3057
AHOH3060

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 2165
ChainResidue
APRO1129
ASER1130
AVAL1131
AASN1132
AGLY1133

site_idAC8
Number of Residues13
DetailsBINDING SITE FOR RESIDUE W2E A 2166
ChainResidue
AHIS1031
AGLY1032
APHE1035
AARG1047
AALA1049
ATYR1050
ATYR1060
ALYS1067
ASER1068
ATYR1071
AILE1075
AGLU1138
AHOH3115

site_idAC9
Number of Residues14
DetailsBINDING SITE FOR RESIDUE W2E C 2165
ChainResidue
CHIS1031
CGLY1032
CPHE1035
CARG1047
CHIS1048
CALA1049
CTYR1050
CTYR1060
CLYS1067
CSER1068
CTYR1071
CILE1075
CGLU1138
CHOH3101

site_idBC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL C 2166
ChainResidue
CGLU978
CHIS979
CGLY982
CGLY983
CGLY987
CILE988
CPHE989
CHOH3033
CHOH3037
CHOH3051

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O95271
ChainResidueDetails
ACYS1081
AHIS1084
ACYS1089
ACYS1092
CCYS1081
CHIS1084
CCYS1089
CCYS1092

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PDB entries from 2024-10-30

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