4BUB

CRYSTAL STRUCTURE OF MURE LIGASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004326	molecular_function	tetrahydrofolylpolyglutamate synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0007049	biological_process	cell cycle
A	0008360	biological_process	regulation of cell shape
A	0009058	biological_process	biosynthetic process
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016874	molecular_function	ligase activity
A	0016881	molecular_function	acid-amino acid ligase activity
A	0046901	biological_process	tetrahydrofolylpolyglutamate biosynthetic process
A	0047482	molecular_function	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity
A	0051301	biological_process	cell division
A	0071555	biological_process	cell wall organization
A	0102195	molecular_function	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004326	molecular_function	tetrahydrofolylpolyglutamate synthase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0007049	biological_process	cell cycle
B	0008360	biological_process	regulation of cell shape
B	0009058	biological_process	biosynthetic process
B	0009252	biological_process	peptidoglycan biosynthetic process
B	0009396	biological_process	folic acid-containing compound biosynthetic process
B	0016874	molecular_function	ligase activity
B	0016881	molecular_function	acid-amino acid ligase activity
B	0046901	biological_process	tetrahydrofolylpolyglutamate biosynthetic process
B	0047482	molecular_function	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity
B	0051301	biological_process	cell division
B	0071555	biological_process	cell wall organization
B	0102195	molecular_function	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP A 1486

Chain	Residue
A	THR111
A	ALA351
A	LYS354
A	MG1487
A	ASN112
A	GLY113
A	LYS114
A	THR115
A	THR116
A	ASN200
A	ASN296
A	ARG327

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1487

Chain	Residue
A	THR137
A	GLU177
A	ADP1486

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP B 1486

Chain	Residue
B	THR111
B	ASN112
B	GLY113
B	LYS114
B	THR115
B	GLU177
B	ASN200
B	PHE292
B	ASN296
B	ARG327
B	MG1487

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 1487

Chain	Residue
B	THR115
B	THR137
B	ADP1486

---

Functional Information from PROSITE/UniProt

site_id	PS01011
Number of Residues	24
Details	FOLYLPOLYGLU_SYNT_1 Folylpolyglutamate synthase signature 1. FgVTGTNGKtTttmmIyHMLtsl.G

Chain	Residue	Details
A	PHE106-GLY129

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	SER32
B	ARG187
A	THR152
A	SER179
A	GLN185
A	ARG187
B	SER32
B	THR152
B	SER179
B	GLN185

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLY110
B	GLY110

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-carboxylysine => ECO:0000250

Chain	Residue	Details
A	LYS219
B	LYS219

---