4BQS

Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004765	molecular_function	shikimate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019632	biological_process	shikimate metabolic process
A	0019752	biological_process	carboxylic acid metabolic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004765	molecular_function	shikimate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0009423	biological_process	chorismate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019632	biological_process	shikimate metabolic process
B	0019752	biological_process	carboxylic acid metabolic process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004765	molecular_function	shikimate kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0009423	biological_process	chorismate biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019632	biological_process	shikimate metabolic process
C	0019752	biological_process	carboxylic acid metabolic process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP A 1171

Chain	Residue
A	LEU10
A	ARG153
A	PRO155
A	HOH2007
A	PRO11
A	GLY12
A	SER13
A	GLY14
A	LYS15
A	SER16
A	THR17
A	ARG110

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP B 1171

Chain	Residue
B	LEU10
B	PRO11
B	GLY12
B	SER13
B	GLY14
B	LYS15
B	SER16
B	THR17
B	ARG110
B	THR150
B	ARG153
B	PRO155
B	HOH2007

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP C 1171

Chain	Residue
C	LEU10
C	PRO11
C	GLY12
C	SER13
C	GLY14
C	LYS15
C	SER16
C	THR17
C	ARG110
C	THR150
C	ARG152
C	HOH2006

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE K2Q A 1172

Chain	Residue
A	ASP34
A	ARG58
A	GLY79
A	GLY80
A	GLY81
A	LEU119
A	ARG136
A	HOH2006
A	HOH2026
A	HOH2039
A	HOH2052

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE K2Q B 1172

Chain	Residue
B	ASP34
B	ARG58
B	GLY79
B	GLY80
B	GLY81
B	LEU119
B	ARG136
B	HOH2006
B	HOH2020
B	HOH2031
B	HOH2041

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE K2Q C 1172

Chain	Residue
C	ASP34
C	PHE57
C	ARG58
C	GLY79
C	GLY80
C	LEU119
C	ARG136
C	HOH2005
C	HOH2022
C	HOH2037
C	HOH2048

---

Functional Information from PROSITE/UniProt

site_id	PS01128
Number of Residues	26
Details	SHIKIMATE_KINASE Shikimate kinase signature. RriEedvVraaladhdg...VLSlGGGaV

Chain	Residue	Details
A	ARG58-VAL83

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Region: {"description":"LID domain"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

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