4BQS
Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004765 | molecular_function | shikimate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0019632 | biological_process | shikimate metabolic process |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004765 | molecular_function | shikimate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0019632 | biological_process | shikimate metabolic process |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004765 | molecular_function | shikimate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0019632 | biological_process | shikimate metabolic process |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ADP A 1171 |
| Chain | Residue |
| A | LEU10 |
| A | ARG153 |
| A | PRO155 |
| A | HOH2007 |
| A | PRO11 |
| A | GLY12 |
| A | SER13 |
| A | GLY14 |
| A | LYS15 |
| A | SER16 |
| A | THR17 |
| A | ARG110 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADP B 1171 |
| Chain | Residue |
| B | LEU10 |
| B | PRO11 |
| B | GLY12 |
| B | SER13 |
| B | GLY14 |
| B | LYS15 |
| B | SER16 |
| B | THR17 |
| B | ARG110 |
| B | THR150 |
| B | ARG153 |
| B | PRO155 |
| B | HOH2007 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ADP C 1171 |
| Chain | Residue |
| C | LEU10 |
| C | PRO11 |
| C | GLY12 |
| C | SER13 |
| C | GLY14 |
| C | LYS15 |
| C | SER16 |
| C | THR17 |
| C | ARG110 |
| C | THR150 |
| C | ARG152 |
| C | HOH2006 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE K2Q A 1172 |
| Chain | Residue |
| A | ASP34 |
| A | ARG58 |
| A | GLY79 |
| A | GLY80 |
| A | GLY81 |
| A | LEU119 |
| A | ARG136 |
| A | HOH2006 |
| A | HOH2026 |
| A | HOH2039 |
| A | HOH2052 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE K2Q B 1172 |
| Chain | Residue |
| B | ASP34 |
| B | ARG58 |
| B | GLY79 |
| B | GLY80 |
| B | GLY81 |
| B | LEU119 |
| B | ARG136 |
| B | HOH2006 |
| B | HOH2020 |
| B | HOH2031 |
| B | HOH2041 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE K2Q C 1172 |
| Chain | Residue |
| C | ASP34 |
| C | PHE57 |
| C | ARG58 |
| C | GLY79 |
| C | GLY80 |
| C | LEU119 |
| C | ARG136 |
| C | HOH2005 |
| C | HOH2022 |
| C | HOH2037 |
| C | HOH2048 |
Functional Information from PROSITE/UniProt
| site_id | PS01128 |
| Number of Residues | 26 |
| Details | SHIKIMATE_KINASE Shikimate kinase signature. RriEedvVraaladhdg...VLSlGGGaV |
| Chain | Residue | Details |
| A | ARG58-VAL83 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Region: {"description":"LID domain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {} |
| Chain | Residue | Details |
