4BOQ

Structure of OTUD2 OTU domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
A	0030433	biological_process	ubiquitin-dependent ERAD pathway
A	0101005	molecular_function	deubiquitinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1310

Chain	Residue
A	GLU235
A	ARG248
A	GLY250
A	GLU251
A	GLY254
A	TYR255
A	SER288

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1311

Chain	Residue
A	PHE286
A	SER287
A	ASP290
A	HOH2111
A	HOH2129
A	ARG273
A	LEU283

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1312

Chain	Residue
A	PRO147
A	ALA177
A	ARG273
A	ILE292
A	HOH2010
A	HOH2111
A	HOH2121
A	HOH2130

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1313

Chain	Residue
A	LYS135
A	TRP212
A	GLY221
A	ALA222
A	ILE223
A	GLU224
A	HOH2062

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	125
Details	Domain: {"description":"OTU","evidences":[{"source":"PROSITE-ProRule","id":"PRU00139","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"Cys-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Region: {"description":"Variable-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Region: {"description":"His-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Region: {"description":"S2 site","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q96FW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BOS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---