4BO5

Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2-chlorophenyl)-4- pyrrol-1-yl-1,3,5-triazin-2-amine at 2.6A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0030497	biological_process	fatty acid elongation
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0030497	biological_process	fatty acid elongation
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0030497	biological_process	fatty acid elongation
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0030497	biological_process	fatty acid elongation
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE WI4 D 1248

Chain	Residue
C	VAL110
C	LEU114
C	ALA159
C	GLY160
D	VAL110
D	LEU114
D	ALA159
D	GLY160

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE WI4 B 1248

Chain	Residue
A	VAL110
A	ALA156
A	ALA159
A	GLY160
A	GLY163
A	PHE164
B	TRP106
B	VAL110
B	LEU114
B	ALA159
B	GLY160
B	GLY163
B	PHE164
A	TRP106

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI D 1250

Chain	Residue
B	GLU55
D	HIS75
D	GLN78
D	HIS79

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgamgnagQtnYAAAKAGLeGFTrALA

Chain	Residue	Details
A	SER141-ALA169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR154
B	TYR154
C	TYR154
D	TYR154

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY12
B	ASP62
B	ASN89
B	SER141
B	TYR154
B	ILE187
C	GLY12
C	THR37
C	ASP62
C	ASN89
C	SER141
A	THR37
C	TYR154
C	ILE187
D	GLY12
D	THR37
D	ASP62
D	ASN89
D	SER141
D	TYR154
D	ILE187
A	ASP62
A	ASN89
A	SER141
A	TYR154
A	ILE187
B	GLY12
B	THR37

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