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4BJK

CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005635cellular_componentnuclear envelope
A0005783cellular_componentendoplasmic reticulum
A0008398molecular_functionsterol 14-demethylase activity
A0016125biological_processsterol metabolic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0044091biological_processmembrane biogenesis
A0046872molecular_functionmetal ion binding
B0004497molecular_functionmonooxygenase activity
B0005506molecular_functioniron ion binding
B0005635cellular_componentnuclear envelope
B0005783cellular_componentendoplasmic reticulum
B0008398molecular_functionsterol 14-demethylase activity
B0016125biological_processsterol metabolic process
B0016491molecular_functionoxidoreductase activity
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0020037molecular_functionheme binding
B0044091biological_processmembrane biogenesis
B0046872molecular_functionmetal ion binding
C0004497molecular_functionmonooxygenase activity
C0005506molecular_functioniron ion binding
C0005635cellular_componentnuclear envelope
C0005783cellular_componentendoplasmic reticulum
C0008398molecular_functionsterol 14-demethylase activity
C0016125biological_processsterol metabolic process
C0016491molecular_functionoxidoreductase activity
C0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C0020037molecular_functionheme binding
C0044091biological_processmembrane biogenesis
C0046872molecular_functionmetal ion binding
D0004497molecular_functionmonooxygenase activity
D0005506molecular_functioniron ion binding
D0005635cellular_componentnuclear envelope
D0005783cellular_componentendoplasmic reticulum
D0008398molecular_functionsterol 14-demethylase activity
D0016125biological_processsterol metabolic process
D0016491molecular_functionoxidoreductase activity
D0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D0020037molecular_functionheme binding
D0044091biological_processmembrane biogenesis
D0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE HEM A 1450
ChainResidue
ATYR103
ALEU356
ALEU359
AARG361
AGLY414
APHE415
AGLY416
AHIS420
ALYS421
ACYS422
AILE423
ATYR116
AGLY424
A18I1460
AARG124
ALEU127
ALEU134
AALA288
AGLY292
ATHR295
ATHR299

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 18I A 1460
ChainResidue
ATYR103
AMET106
APHE110
ATYR116
AGLU205
ALEU208
APHE290
AALA291
AMET460
AVAL461
AHEM1450

site_idAC3
Number of Residues21
DetailsBINDING SITE FOR RESIDUE HEM B 1450
ChainResidue
BTYR103
BTYR116
BARG124
BLEU127
BLEU134
BALA288
BALA291
BGLY292
BTHR295
BTHR299
BLEU359
BARG361
BGLY414
BPHE415
BGLY416
BHIS420
BLYS421
BCYS422
BILE423
BGLY424
B18I1460

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 18I B 1460
ChainResidue
BTYR103
BMET106
BTYR116
BPHE290
BALA291
BMET460
BHEM1450

site_idAC5
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HEM C 1450
ChainResidue
CTYR103
CTYR116
CARG124
CLEU127
CALA288
CALA291
CGLY292
CTHR295
CTHR299
CARG361
CGLY414
CPHE415
CGLY416
CHIS420
CLYS421
CCYS422
CILE423
CGLY424
C18I1460

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE 18I C 1460
ChainResidue
CMET106
CPHE110
CTYR116
CALA291
CHEM1450

site_idAC7
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HEM D 1450
ChainResidue
DCYS422
DILE423
DGLY424
D18I1460
DTYR103
DTYR116
DARG124
DLEU127
DLEU134
DALA288
DALA291
DGLY292
DTHR295
DTHR299
DARG361
DGLY414
DPHE415
DGLY416
DHIS420

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE 18I D 1460
ChainResidue
DMET106
DTYR116
DALA291
DLEU356
DHEM1450

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGVHKCIG
ChainResidueDetails
APHE415-GLY424

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PDB entries from 2024-10-09

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