4BIZ
Crystal structure of CpxAHDC (orthorhombic form 2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| C | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
| C | 0016310 | biological_process | phosphorylation |
| C | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| D | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0016020 | cellular_component | membrane |
| D | 0016310 | biological_process | phosphorylation |
| D | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| E | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| E | 0007165 | biological_process | signal transduction |
| E | 0016020 | cellular_component | membrane |
| E | 0016310 | biological_process | phosphorylation |
| E | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| F | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| F | 0007165 | biological_process | signal transduction |
| F | 0016020 | cellular_component | membrane |
| F | 0016310 | biological_process | phosphorylation |
| F | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP A 501 |
| Chain | Residue |
| A | ASN360 |
| A | THR406 |
| A | ALA409 |
| A | GLY416 |
| A | THR417 |
| A | GLY418 |
| A | LEU419 |
| A | GLY420 |
| A | LEU421 |
| A | LEU445 |
| A | HOH2024 |
| A | ARG363 |
| A | TYR364 |
| A | ASP386 |
| A | PRO389 |
| A | VAL391 |
| A | ILE399 |
| A | TYR404 |
| A | ARG405 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP C 501 |
| Chain | Residue |
| C | ASN360 |
| C | ARG363 |
| C | TYR364 |
| C | ASP386 |
| C | VAL391 |
| C | ILE399 |
| C | TYR404 |
| C | ARG405 |
| C | THR406 |
| C | ALA409 |
| C | GLY416 |
| C | THR417 |
| C | GLY418 |
| C | GLY420 |
| C | LEU421 |
| C | LEU445 |
| C | HOH2045 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP E 501 |
| Chain | Residue |
| E | ARG359 |
| E | ASN360 |
| E | ARG363 |
| E | TYR364 |
| E | ASP386 |
| E | PRO389 |
| E | VAL391 |
| E | ILE399 |
| E | TYR404 |
| E | ARG405 |
| E | THR406 |
| E | ALA409 |
| E | GLY416 |
| E | THR417 |
| E | GLY418 |
| E | GLY420 |
| E | LEU421 |
| E | LEU445 |
| E | HOH2009 |
| E | HOH2010 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP F 501 |
| Chain | Residue |
| F | ASN360 |
| F | ARG363 |
| F | TYR364 |
| F | ASP386 |
| F | GLY390 |
| F | VAL391 |
| F | ILE399 |
| F | TYR404 |
| F | THR406 |
| F | THR417 |
| F | GLY418 |
| F | LEU419 |
| F | GLY420 |
| F | LEU421 |
| F | LEU445 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1456 |
| Chain | Residue |
| A | ARG446 |
| A | HOH2046 |
| E | LYS377 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 F 1457 |
| Chain | Residue |
| C | ARG446 |
| F | LYS377 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 1456 |
| Chain | Residue |
| A | LYS377 |
| A | HOH2032 |
| E | ARG446 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1456 |
| Chain | Residue |
| C | LYS377 |
| F | ARG446 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1457 |
| Chain | Residue |
| B | ARG446 |
| D | LYS377 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1456 |
| Chain | Residue |
| B | LYS377 |
| D | PRO441 |
| D | ARG446 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"24492262","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24492262","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphohistidine; by autocatalysis","evidences":[{"source":"PROSITE-ProRule","id":"PRU00107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24492262","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9401031","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 210 |
| Details | Domain: {"description":"Histidine kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
