4BIU

Crystal structure of CpxAHDC (orthorhombic form 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000155	molecular_function	phosphorelay sensor kinase activity
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0000155	molecular_function	phosphorelay sensor kinase activity
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0000155	molecular_function	phosphorelay sensor kinase activity
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
C	0016310	biological_process	phosphorylation
C	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
D	0000155	molecular_function	phosphorelay sensor kinase activity
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
D	0016310	biological_process	phosphorylation
D	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
E	0000155	molecular_function	phosphorelay sensor kinase activity
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
E	0016310	biological_process	phosphorylation
E	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
F	0000155	molecular_function	phosphorelay sensor kinase activity
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane
F	0016310	biological_process	phosphorylation
F	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP C 501

Chain	Residue
C	ASN360
C	LEU445
C	ARG363
C	TYR364
C	ASP386
C	PRO389
C	VAL391
C	ILE399
C	GLY420
C	LEU421

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP E 501

Chain	Residue
E	ASN360
E	ARG363
E	TYR364
E	ASP386
E	PRO389
E	VAL391
E	ILE399
E	TYR404
E	GLY418
E	LEU419
E	LEU445

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP F 501

Chain	Residue
F	ASN360
F	ARG363
F	TYR364
F	ASP386
F	PRO389
F	VAL391
F	ILE399
F	ARG405
F	THR406
F	ALA409
F	THR417
F	GLY420
F	LEU421
F	LEU445

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 1455

Chain	Residue
C	PRO340
C	TRP341
F	GLY339
F	PRO340
F	TRP341

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1456

Chain	Residue
D	GLY339
D	PRO340
D	TRP341
E	GLY339
E	PRO340
E	TRP341

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1457

Chain	Residue
D	ASN360
D	ARG363
D	TYR364
D	GLY418

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"24492262","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	73
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24492262","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphohistidine; by autocatalysis","evidences":[{"source":"PROSITE-ProRule","id":"PRU00107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24492262","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9401031","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	210
Details	Domain: {"description":"Histidine kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---