4BIK

Structure of a disulfide locked mutant of Intermedilysin with human CD59

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008289	molecular_function	lipid binding
A	0015485	molecular_function	cholesterol binding
A	0016020	cellular_component	membrane
A	0020002	cellular_component	host cell plasma membrane
A	0031640	biological_process	killing of cells of another organism
A	0035821	biological_process	modulation of process of another organism
A	0046872	molecular_function	metal ion binding
A	0090729	molecular_function	toxin activity
C	0005576	cellular_component	extracellular region
C	0008289	molecular_function	lipid binding
C	0015485	molecular_function	cholesterol binding
C	0016020	cellular_component	membrane
C	0020002	cellular_component	host cell plasma membrane
C	0031640	biological_process	killing of cells of another organism
C	0035821	biological_process	modulation of process of another organism
C	0046872	molecular_function	metal ion binding
C	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00983
Number of Residues	44
Details	LY6_UPAR Ly-6 / u-PAR domain signature. QCYnCpnptad..Cktav....NCSsdfdaClitkaglqvynkcwkfeh......C

Chain	Residue	Details
B	GLN2-CYS45

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	LIPID: GPI-anchor amidated asparagine => ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:8276756

Chain	Residue	Details
B	ASN77
D	ASN77

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:8670172

Chain	Residue	Details
B	ASN18
D	ASN18

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:10805801

Chain	Residue	Details
B	LYS41
D	LYS41

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000305

Chain	Residue	Details
B	THR51
B	THR52
D	THR51
D	THR52

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