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4BHB

Crystal structure of Mycobacterium tuberculosis O6-METHYLGUANINE METHYLTRANSFERASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0003908molecular_functionmethylated-DNA-[protein]-cysteine S-methyltransferase activity
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006259biological_processDNA metabolic process
A0006281biological_processDNA repair
A0006307biological_processDNA alkylation repair
A0008168molecular_functionmethyltransferase activity
A0032259biological_processmethylation
A0051409biological_processresponse to nitrosative stress
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 1166
ChainResidue
AMET28
AARG145
AHOH2011
AHOH2107

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1167
ChainResidue
AILE123
AHOH2047
AHIS39
APHE65
AVAL67
ALEU69
ALEU85

Functional Information from PROSITE/UniProt
site_idPS00374
Number of Residues7
DetailsMGMT Methylated-DNA--protein-cysteine methyltransferase active site. VPCHRVI
ChainResidueDetails
AVAL124-ILE130

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Nucleophile; methyl group acceptor => ECO:0000255|HAMAP-Rule:MF_00772
ChainResidueDetails
ACYS126

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PDB entries from 2024-07-17

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