Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4BFR

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

Functional Information from GO Data
ChainGOidnamespacecontents
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0016301molecular_functionkinase activity
B0016303molecular_function1-phosphatidylinositol-3-kinase activity
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE J82 A 2000
ChainResidue
ATYR772
AVAL848
AMET920
AILE930
AASP931
AHOH2019
AMET773
APRO779
ATRP781
AILE797
ALYS799
ATYR833
AGLU846
AVAL847

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE J82 B 2000
ChainResidue
BTYR772
BMET773
BPRO779
BTRP781
BLYS799
BTYR833
BGLU846
BVAL847
BVAL848
BMET920
BPHE928
BILE930
BASP931
BHOH2033

Functional Information from PROSITE/UniProt
site_idPS00430
Number of Residues99
DetailsTONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. gekldskigvligkglhefdalkdpevnefrrkmrkfseakiqslvglswidwlkhtyppehepsvlenledklyggklvvavhfensqdv........................FSFQVSPN
ChainResidueDetails
AGLY113-ASN211

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ
ChainResidueDetails
APHE798-GLN812

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVasYVLgIgDRHsdN
ChainResidueDetails
ASER898-ASN918

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER318
BSER318

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P42338
ChainResidueDetails
ASER1064
BSER1064

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon