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4BFR

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

Functional Information from GO Data
ChainGOidnamespacecontents
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0016301molecular_functionkinase activity
B0016303molecular_function1-phosphatidylinositol-3-kinase activity
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE J82 A 2000
ChainResidue
ATYR772
AVAL848
AMET920
AILE930
AASP931
AHOH2019
AMET773
APRO779
ATRP781
AILE797
ALYS799
ATYR833
AGLU846
AVAL847

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE J82 B 2000
ChainResidue
BTYR772
BMET773
BPRO779
BTRP781
BLYS799
BTYR833
BGLU846
BVAL847
BVAL848
BMET920
BPHE928
BILE930
BASP931
BHOH2033

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues16
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

260320

PDB entries from 2026-09-30

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