Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4BED

Keyhole limpet hemocyanin (KLH): 9A cryoEM structure and molecular model of the KLH1 didecamer reveal the interfaces and intricate topology of the 160 functional units

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CUO A 9001

Chain	Residue
A	HIS42
A	HIS60
A	PHE65
A	HIS69
A	HIS179
A	HIS183
A	PHE206
A	HIS210

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CUO A 9002

Chain	Residue
A	CYS480
A	HIS482
A	HIS491
A	HIS602
A	HIS606
A	PHE629
A	HIS633
A	HIS462

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CUO A 9003

Chain	Residue
A	HIS876
A	CYS894
A	HIS896
A	HIS905
A	HIS1015
A	HIS1019
A	HIS1046

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CUO A 9004

Chain	Residue
A	HIS1293
A	HIS1311
A	HIS1320
A	HIS1424
A	HIS1428
A	PHE1451
A	HIS1455

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CUO B 9005

Chain	Residue
B	HIS1705
B	HIS1725
B	HIS1734
B	HIS1847
B	HIS1851
B	PHE1874
B	HIS1878

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CUO B 9006

Chain	Residue
B	HIS2122
B	CYS2139
B	HIS2141
B	PHE2146
B	HIS2150
B	HIS2260
B	HIS2264
B	PHE2287
B	HIS2291

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CUO B 9007

Chain	Residue
B	HIS2542
B	HIS2561
B	HIS2570
B	HIS2670
B	HIS2674
B	PHE2697
B	HIS2701

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CUO B 9008

Chain	Residue
B	HIS2946
B	CYS2963
B	HIS2965
B	HIS2974
B	HIS3075
B	HIS3079
B	PHE3102
B	HIS3106

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CUO C 9001

Chain	Residue
C	HIS42
C	HIS60
C	PHE65
C	HIS69
C	HIS179
C	HIS183
C	PHE206
C	HIS210

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CUO C 9002

Chain	Residue
C	HIS462
C	CYS480
C	HIS482
C	HIS491
C	HIS602
C	HIS606
C	PHE629
C	HIS633

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CUO C 9003

Chain	Residue
C	HIS876
C	CYS894
C	HIS896
C	HIS905
C	HIS1015
C	HIS1019
C	HIS1046

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CUO C 9004

Chain	Residue
C	HIS1293
C	HIS1311
C	HIS1320
C	HIS1424
C	HIS1428
C	PHE1451
C	HIS1455

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CUO D 9005

Chain	Residue
D	HIS1705
D	HIS1725
D	PHE1730
D	HIS1734
D	HIS1847
D	HIS1851
D	PHE1874
D	HIS1878

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CUO D 9006

Chain	Residue
D	HIS2122
D	HIS2141
D	HIS2150
D	HIS2260
D	HIS2264
D	PHE2287
D	HIS2291

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CUO D 9007

Chain	Residue
D	HIS2542
D	HIS2561
D	PHE2566
D	HIS2570
D	HIS2670
D	HIS2674
D	HIS2701

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CUO D 9008

Chain	Residue
D	HIS2946
D	CYS2963
D	HIS2965
D	HIS2974
D	HIS3075
D	HIS3079
D	PHE3102
D	HIS3106

Functional Information from PROSITE/UniProt

site_id	PS00497
Number of Residues	18
Details	TYROSINASE_1 Tyrosinase CuA-binding region signature. Hgmpt.FPhWHRayVvhmE

Chain	Residue	Details
A	HIS60-GLU77
A	HIS482-GLU499
A	HIS896-GLU913
A	HIS1311-GLU1328
B	HIS2141-GLU2158
B	HIS2561-GLU2578
B	HIS2965-GLU2982

site_id	PS00498
Number of Residues	12
Details	TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPiFFlhHsnvD

Chain	Residue	Details
A	ASP203-ASP214
A	ASP626-ASP637
A	ASP1039-ASP1050
A	ASP1448-ASP1459
B	ASP1871-ASP1882
B	ASP2284-ASP2295
B	ASP2694-ASP2705
B	ASP3099-ASP3110

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	82
Details	Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	82
Details	Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	82
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	840
Details	Region: {"description":"Functional unit a (wall)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	826
Details	Region: {"description":"Functional unit b (wall)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	838
Details	Region: {"description":"Functional unit c (wall)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	816
Details	Region: {"description":"Functional unit d (wall)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	90
Details	Binding site: {"evidences":[{"source":"PDB","id":"4BED","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	32
Details	Cross-link: {"description":"2'-(S-cysteinyl)-histidine (Cys-His)","evidences":[{"source":"UniProtKB","id":"P56824","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Cross-link: {"description":"2'-(S-cysteinyl)-histidine (Cys-His)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	82
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	72
Details	Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	82
Details	Repeat: {"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	82
Details	Repeat: {"description":"WD 7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	832
Details	Region: {"description":"Functional unit e (wall)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	838
Details	Region: {"description":"Functional unit f (wall)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	806
Details	Region: {"description":"Functional unit g (internal arc)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	984
Details	Region: {"description":"Functional unit h (internal slab)","evidences":[{"source":"PubMed","id":"19013468","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PDB","id":"3QJO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BED","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)